Preparation of PLLA/PEG Nanofibers by Electrospinning and Potential Applications

Spasova, Mariya; Stoilova, Olya; Manolova, Nevena; Rashkov, Iliya; Altankov, George

doi:10.1177/0883911506073570

Cited by 89 publications

(63 citation statements)

References 18 publications

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“…The increase of solution viscosity is associated with an increase in the number of molecular entanglements per polymer chain and the lower amount of solvents present due to the increased solution concentration. The increase in viscosity is regarded as an important factor for the formation of a stable jet as it compensates for the increased surface tension [18].…”

Section: Effect Of Polymer Concentrationmentioning

confidence: 99%

Electrospun PLA: PCL composites embedded with unmodified and 3-aminopropyltriethoxysilane (ASP) modified halloysite nanotubes (HNT)

et al. 2012

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Electrospinning is a simple and versatile fiber synthesis technique in which a highvoltage electric field is applied to a stream of polymer melt or polymer solution, resulting in the formation of continuous micro/nanofibers. Halloysite nanotubes (HNT) have been found to achieve improved structural and mechanical properties when embedded into various polymer matrices. This research work focuses on blending poly(ε-caprolactone) (PCL) (9 wt%/v and 15 wt%/v) and poly(lactic acid) (PLA) (fixed at 8 wt%/v) solutions with HNT at two different concentrations 1 wt%/v and 2 wt%/v. Both unmodified HNT and HNT modified with 3-aminopropyltriethoxysilane (ASP) were utilized in this study. Furthermore, the addition of HNT-ASP to the polymeric blends resulted in a moderate decrease in the degree of crystallinity, as well as slight reductions of glass transition temperature of PCL, the crystallization temperature and melting temperature of PLA within composite materials. The infrared spectra of composites confirmed the successful embedding of HNT-ASP into PLA: PCL nanofibers relative to unmodified HNT due to the premodification using ASP to reduce the agglomeration behavior. This study provides a new material system that could be potentially used in drug delivery, and may facilitate good control of the drug release process.

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Section: Effect Of Polymer Concentrationmentioning

confidence: 99%

Electrospun PLA: PCL composites embedded with unmodified and 3-aminopropyltriethoxysilane (ASP) modified halloysite nanotubes (HNT)

et al. 2012

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“…Nanofiber mats from many different types of polymers have been evaluated for their cytocompatibility to fibroblast and/or keratinocytes. The polymers studied include natural polymers, such as SF [57,107,108] , collagen [109][110][111][112] , gelatin [113] , chitosan [82,114] , hyaluronic acid (HA) [115,116] , and synthetic polymers such as PLGA [73,117] , PLLA [118][119][120][121][122] , PCL [123][124][125][126][127] and many others [128 -131] . In most cases, the electrospun nanofiber mats exhibited good capability of supporting cell attachment and proliferation.…”

Section: Skinsmentioning

confidence: 99%

Applications of electrospun nanofibers

et al. 2008

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“…The usage of PEG is similar to that of PEO because of its identical monomeric units, but the low M w PEG has been more useful in generating block copolymer strategies [59,60]. PEG was also used early on in the context of the core-shell technique (which will be discussed in greater detail in Sect.…”

Section: Soluble Polymers: Peo Peg and Pvamentioning

confidence: 98%

Synthetic/Biopolymer Nanofibrous Composites as Dynamic Tissue Engineering Scaffolds

Kluge

Mauck

2011

Biomedical Applications of Polymeric Nanofibers

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Synthetic/biopolymer composite scaffolds can provide improved flexibility when designing optimized stem-cell-laden tissue repair devices for fiberreinforced tissues. Composites enable a range of mechanical properties, rates of degradation, and other functional attributes of a degradable scaffold to be finely tuned by modifying polymer sources and their processing techniques. Furthermore, marrying synthetic fibers spun from harsh solvents with polymers spun from mild organic or aqueous-based solvents can allow for delivery of active molecular species in these composites. In the pre-processing fabrication steps, polymers can be selected and combined from traditional or newer high-throughput approaches into networks with properties that reflect the individual components or their interactions. These properties may also depend on the spinning solvents used. In post-processing steps, factors such as the ambient environmental conditions or crosslinking solvent treatments can differentially affect the constituent polymers chosen. Several case studies will be discussed in order to highlight the potential advantages of these approaches. For example, many studies have shown that the mechanical properties of composite mats can be designed with superior or more tissue-like properties than individual polymer sources alone. Further, it has been shown that the degradation rates of the temporary scaffold can be more finely tuned in composites by combining rapidly and slowly degrading systems. The drug and growth factor delivery capabilities of these systems will similarly be reviewed. We conclude with an overview of several tissue engineering approaches that have exploited composite design features and discuss new promising avenues for study.

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Preparation of PLLA/PEG Nanofibers by Electrospinning and Potential Applications

Cited by 89 publications

References 18 publications

Electrospun PLA: PCL composites embedded with unmodified and 3-aminopropyltriethoxysilane (ASP) modified halloysite nanotubes (HNT)

Electrospun PLA: PCL composites embedded with unmodified and 3-aminopropyltriethoxysilane (ASP) modified halloysite nanotubes (HNT)

Applications of electrospun nanofibers

Synthetic/Biopolymer Nanofibrous Composites as Dynamic Tissue Engineering Scaffolds

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