Preparation of PLGA/Rose Bengal colloidal particles by double emulsion and layer-by-layer for breast cancer treatment

Loya-Castro, María F.; Sánchez-Mejía, Mariana; Sánchez-Ramírez, Dante R.; Domínguez-Ríos, Rossina; Escareño, Noé; Oceguera-Basurto, Paola E.; Figueroa-Ochoa, Édgar B.; Quintero, A; Toro-Arreola, Alicia del; Topete, Antonio; Daneri-Navarro, ́Adrián

doi:10.1016/j.jcis.2018.02.013

Cited by 23 publications

(8 citation statements)

References 37 publications

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“…The quantity of integrated hydrophilic drug, the stabilizer concentration, the polymer concentration, and the volume of aqueous phase all have a role in the characterization of nanoparticles in this procedure [ 63 ]. Some examples for drugs nano-formulations prepared by double emulsion technique include Rose Bengal for breast cancer treatment [ 64 ] and oleuropein with improved stability [ 65 ].…”

Section: Main Textmentioning

confidence: 99%

Pharmaceutical nanotechnology: from the bench to the market

et al. 2022

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Background Nanotechnology is considered a new and rapidly emerging area in the pharmaceutical and medicinal field. Nanoparticles, as drug delivery systems, impart several advantages concerning improved efficacy as well as reduced adverse drug reactions. Main body Different types of nanosystems have been fabricated including carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, etc. Physicochemical properties of the starting materials and the selected method of preparation play a significant aspect in determining the shape and characteristics of the developed nanoparticles. Dispersion of preformed polymers, coacervation, polymerization, nano-spray drying and supercritical fluid technology are among the most extensively used techniques for the preparation of nanocarriers. Particle size, surface charge, surface hydrophobicity and drug release are the main factors affecting nanoparticles physical stability and biological performance of the incorporated drug. In clinical practice, many nanodrugs have been used for both diagnostic and therapeutic applications and are being investigated for various indications in clinical trials. Nanoparticles are used for the cure of kidney diseases, tuberculosis, skin conditions, Alzheimer’s disease, different types of cancer as well as preparation of COVID-19 vaccines. Conclusion In this review, we will confer the advantages, types, methods of preparation, characterization methods and some of the applications of nano-systems.

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Section: Main Textmentioning

confidence: 99%

Pharmaceutical nanotechnology: from the bench to the market

et al. 2022

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“…There are also many complex multiple emulsions with more than two dispersed phases i. e. triple, quadruple and higher-order emulsions. These dispersed systems prepared mostly on the base of polymers offer a wide applications range in chemistry and chemical engineering (separation processes and environmental protection) and their interdisciplinary fields, such as pharmacy and medicine, especially for the encapsulation and controlled release of active ingredients (drugs, stem cells, nutrients, cosmetics, food) [15][16][17][18]. In medical engineering, they can be used as a chemotherapy drug carriers with reduced toxicity and increased selectivity when compared to conventional chemotherapeutic agents used clinically in targeting cancer [13,15,17].…”

Section: Emulsje Wielokrotne Z Ph-czułym Biopolimerem Wytwarzane W Ko...mentioning

confidence: 99%

A pH-responsive biopolymer-based multiple emulsion prepared in a helicoidal contactor for chemotherapeutics delivery

Dłuska

Markowska-Radomska

Skowroński

2022

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Among biopolymers, pH-responsive ones have much potential for drug delivery systems by exploiting the pH gradient between physiological and pathological states. In this paper multiple emulsions with a pH-responsive biopolymer for controlled drug delivery in brain tumor treatment were discussed. The characteristic and rheological properties of multiple emulsions, biopolymer adsorption, zeta potential, and release processes were examined. The results showed higher drug release rates in the acidic tumor microenvironment compared to the simulated conditions of normal cells.

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“…These dispersed systems offer a wide range of possible applications in separation processes and environmental protection (alternative fuel), pharmaceuticals, and medicine, especially for the encapsulation and controlled release of active ingredients (drugs, living cells, antigen delivery, cosmetics, food). 17,18,19,20,21,22,23,24,25 Controlling by multiple emulsions is achieved through the size and physicochemical parameters of drops forming liquid-permeable membranes separating the internal droplets from the continuous external phase. The proposed method involves inserting the liquid implant intraoperatively into the cavity after surgical resection of the tumour, Fig.…”

Section: Introductionmentioning

confidence: 99%

Mass transfer of anti-cancer drug delivery to brain tumours by a multiple emulsion-based implant

Dłuska¹,

Markowska-Radomska²,

Metera³

et al. 2021

Preprint

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The advanced use of a pH-responsive biomaterial-based injectable liquid implant for effective chemotherapeutic delivery in glioblastoma multiforme brain (GBM) tumour treatment is presented. As an implant, we proposed a water-in-oil-in-water multiple emulsion with encapsulated doxorubicin. The effectiveness of the proposed therapy was evaluated by comparing the cancer cell viability achieved in classical therapy (chemotherapeutic solution). The experimental study included doxorubicin release rates and consumption for two emulsions differing in drop sizes and structures in the presence of GBM-cells (LN229, U87 MG), and a cell viability. The results showed that the multiple emulsion implant was significantly more effective than classical therapy when considering the reduction in cancer cell viability: 85% for the emulsion-implant, and only 43% for the classical therapy. A diffusion-reaction model was adapted to predict doxorubicin release kinetics and elimination by glioblastoma cells. CFD simulations confirmed that the drug release kinetics depends on multiple emulsion structures and drop sizes.

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Preparation of PLGA/Rose Bengal colloidal particles by double emulsion and layer-by-layer for breast cancer treatment

Cited by 23 publications

References 37 publications

Pharmaceutical nanotechnology: from the bench to the market

Pharmaceutical nanotechnology: from the bench to the market

A pH-responsive biopolymer-based multiple emulsion prepared in a helicoidal contactor for chemotherapeutics delivery

Mass transfer of anti-cancer drug delivery to brain tumours by a multiple emulsion-based implant

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