Preparation of plasticized poly (lactic acid) and its influence on the properties of composite materials

Li, Decai; Jiang, Yang; Lv, Shanshan; Liu, Xiaojing; Gu, Jiyou; Chen, Qifeng; Zhang, Yanhua

doi:10.1371/journal.pone.0193520

Cited by 92 publications

(80 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Young’s modulus and tensile strength increase after incorporation of R into PLA and decrease in plasticized PLA, while as is expected, the elongation at break increased and is two times higher for plasticized systems containing R– as revealed in Figure 5 . An increase in the elongation at break and a decrease in the tensile strength for PLA/PEG4000 blends were previously reported [ 61 ], with ~7% elongation at break for the PLA/PEG4000 blend [ 62 ]. The mechanical properties are kept within satisfactory limits with improved elasticity for plasticized samples in the presence of R. Examples in the literature present a lack of systems containing PLA/rosemary, mostly using essential oils; therefore, it is difficult to compare results with different types of materials processed in other conditions.…”

Section: Resultsmentioning

confidence: 60%

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

Darie-Niță¹,

Vasile²,

Stoleru³

et al. 2018

Materials

View full text Add to dashboard Cite

New multifunctional materials containing additives derived from natural resources as powdered rosemary ethanolic extract were obtained by melt mixing and processed in good conditions without degradation and loss of additives. Incorporation of powdered rosemary ethanolic extract (R) into poly(lactic acid) (PLA) improved elongation at break, rheological properties, antibacterial and antioxidant activities, in addition to the biocompatibility. The good accordance between results of the chemiluminescence method and radical scavenging activity determination by chemical method evidenced the increased thermoxidative stability of the PLA biocomposites with respect to neat PLA, with R acting as an antioxidant. PLA/R biocomposites also showed low permeability to gases and migration rates of the bioactive compounds and could be considered as high-performance materials for food packaging. In vitro biocompatibility based on the determination of surface properties demonstrated a good hydrophilicity, better spreading and division of fibroblasts, and increased platelet cohesion. The implantation of PLA/R pellets, was proven to possess a good in vivo biocompatibility, and resulted in similar changes in blood parameters and biochemical responses with the control group, suggesting that these PLA-based materials demonstrate very desirable properties as potential biomaterials, useful in human medicine for tissue engineering, wound management, orthopedic devices, scaffolds, drug delivery systems, etc. Therefore, PLA/R-based materials show promising properties for applications both in food packaging and as bioactive biomaterials.

show abstract

Section: Resultsmentioning

confidence: 60%

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

Darie-Niță¹,

Vasile²,

Stoleru³

et al. 2018

Materials

View full text Add to dashboard Cite

show abstract

“…An absorption band centered at 1455 cm −1 of the -CH 3 group decreases when the ATBC relation increase [ 26 ]; while the bands centered at 1455 cm −1 , 1358 cm −1 and 1212 cm −1 become wider [ 27 , 42 ]. The typical absorption of the C-O asymmetric stretching in the ester group appear centered at 1182 cm −1 [ 19 ] and also decrease for the ATBC interaction [ 27 ]; finally, the bands at 868 and 754 cm −1 correspond to the amorphous and crystalline phases of PLA, indicating a semi crystalline plasticized PLA [ 13 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Several plasticizers have been used to improve the undesirable processing properties of the PLA; they include low and high molecular weight plasticizers depending of the required mobility within the PLA matrix [ 14 , 18 , 19 ]. Some of the most high molecular weight plasticizers reported are polyethylene glycol (PEG), acrylated polyethyleneglycol (PEGA), lactic acid oligomer (LAO), citrate oligoesteres, and malonate oligomers.…”

Section: Introductionmentioning

confidence: 99%

Effect of Extrusion Screw Speed and Plasticizer Proportions on the Rheological, Thermal, Mechanical, Morphological and Superficial Properties of PLA

et al. 2020

View full text Add to dashboard Cite

One of the critical processing parameters—the speed of the extrusion process for plasticized poly (lactic acid) (PLA)—was investigated in the presence of acetyl tributyl citrate (ATBC) as plasticizer. The mixtures were obtained by varying the content of plasticizer (ATBC, 10–30% by weight), using a twin screw extruder as a processing medium for which a temperature profile with peak was established that ended at 160 °C, two mixing zones and different screw rotation speeds (60 and 150 rpm). To evaluate the thermo-mechanical properties of the blend and hydrophilicity, the miscibility of the plasticizing and PLA matrix, Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), oscillatory rheological analysis, Dynamic Mechanical Analysis (DMA), mechanical analysis, as well as the contact angle were tested. The results derived from the oscillatory rheological analysis had a viscous behavior in the PLA samples with the presence of ATBC; the lower process speed promotes the transitions from viscous to elastic as well as higher values of loss modulus, storage modulus and complex viscosity, which means less loss of molecular weight and lower residual energy in the transition from the viscous state to the elastic state. The mechanical and thermal performance was optimized considering a greater capacity in the energy absorption and integration of the components.

show abstract

“…Its hydrophilicity can improve aqueous solubility and bioavailability of solid dispersion. PEG has also been effectively used as a plasticiser in polymer matrices [33][34][35]. By adding Eudragit and PEG into the formulation, the flexibility and plasticity of HPC filament can be improved so that it can be used for 3D printing.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

2019

View full text Add to dashboard Cite

This study reports a thorough investigation combining hot-melt extrusion technology (HME) and a low-cost fused deposition modelling (FDM) 3D printer as a continuous fabrication process for a sustained release drug delivery system. The successful implementation of such an approach presented herein allows local hospitals to manufacture their own medical and pharmaceutical products on-site according to their patients' needs. This will help save time from waiting for suitable products to be manufactured off-site or using traditional manufacturing processes. The filaments were produced by optimising various compositions of pharmaceutical-grade polymers, such as hydroxypropyl cellulose (HPC), Eudragit ® (RL PO), and polyethylene glycol (PEG), whereas theophylline was used as a model thermally stable drug. For the purpose of the study, twin-screw hot-melt extrusion (HME) was implemented from the view that it would result in the formation of solid dispersion of drug in the polymeric carrier matrices by means of high shear mixing inside the heated barrel. Four filament compositions consisting of different ratios of polymers were produced and their properties were assessed. The mechanical characterisation of the filaments revealed quite robust properties of the filaments suitable for FDM 3D printing of caplets (PrintCap), whereas the solid-state analyses conducted via DSC and XRD showed amorphous nature of the crystalline drug dispersed in the polymeric matrices. Moreover, the surface analysis conducted via SEM showed a smooth surface of the produced filaments as well as caplets where no drug crystals were visible. The in vitro drug release study showed a sustained release profile over 10 h where about 80% of the drug was released from the printed dosage forms. This indicates that our optimised 3D printed caplets could be suitable for the development of sustained release on-demand drug delivery systems.Polymers 2020, 12, 27 2 of 18 3D printing should be able to produce these medicines, in particular, the solid dosage forms that are adjusted according to the patient's need [3]. The use of 3D printing in producing medicines also allows hospitals and pharmacies to manufacture the medications for patients immediately after consultation. This is particularly beneficial for hospitals in remote areas so that they can supply their own patients with just-in-time medications. Apart from that, 3D printing can be used to produce dosage forms with complex shapes and different release patterns cost-effectively, which can otherwise be relatively expensive and difficult to achieve with traditional manufacturing methods [4][5][6]. It is quite difficult to produce products with high complexity via traditional pharmaceutical processes such as compression and encapsulation, and it is not effective in terms of producing personalised products [7]. With 3D printing, it is possible to fabricate medicines of different shapes, sizes, and structures to tailor the release patterns of the drug [8]. It is also more cost-effective to produce personalise...

show abstract

Preparation of plasticized poly (lactic acid) and its influence on the properties of composite materials

Cited by 92 publications

References 31 publications

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

Effect of Extrusion Screw Speed and Plasticizer Proportions on the Rheological, Thermal, Mechanical, Morphological and Superficial Properties of PLA

Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

Contact Info

Product

Resources

About