Preparation of photothermal responsive and ROS generative gold nanocages for cancer therapy

Hu, Yanan; Huang, Sichao; Zhao, Xian; Chang, Linna; Ren, Xiuli; Mei, Xifan; Chen, Zhenhua

doi:10.1016/j.cej.2021.129744

Cited by 37 publications

(19 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on strong photothermal effects, plasmonic gold nanomaterials have been intensively investigated for cancer therapy, wound healing, and antibacterial applications [29][30][31][32][33]. For example, a plasmonic gold nanocage-based anticancer nanoplatform that was photothermally responsive in the near-infrared (NIR) region was employed to treat MCF-7 tumors [34]. Nanomaterials of the lipid bilayer coated with reduced graphene oxide and gold nanostars exhibited outstanding anticancer efficacy against pancreatic cancer tumors in mice due to their synergistic photothermal and gene therapies [35].…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Gold Nanoisland Film for Bacterial Theranostics

et al. 2021

View full text Add to dashboard Cite

Plasmonic nanomaterials have been intensively explored for applications in biomedical detection and therapy for human sustainability. Herein, plasmonic gold nanoisland (NI) film (AuNIF) was fabricated onto a glass substrate by a facile seed-mediated growth approach. The structure of the tortuous gold NIs of the AuNIF was demonstrated by scanning electron microscopy and energy-dispersive X-ray spectroscopy. Based on the ultraviolet-visible spectrum, the AuNIF revealed plasmonic absorption with maximum intensity at 624 nm. With the change to the surface topography created by the NIs, the capture efficiency of Escherichia coli (E. coli) by the AuNIF was significantly increased compared to that of the glass substrate. The AuNIF was applied as a surface-enhanced Raman scattering (SERS) substrate to enhance the Raman signal of E. coli. Moreover, the plasmonic AuNIF exhibited a superior photothermal effect under irradiation with simulated AM1.5 sunlight. For photothermal therapy, the AuNIF also displayed outstanding efficiency in the photothermal killing of E. coli. Using a combination of SERS detection and photothermal therapy, the AuNIF could be a promising platform for bacterial theranostics.

show abstract

Section: Introductionmentioning

confidence: 99%

Plasmonic Gold Nanoisland Film for Bacterial Theranostics

et al. 2021

View full text Add to dashboard Cite

show abstract

“…After pioneering synthesis studies, the Xia group reported the first biomedical applications of AuNCG-based bioconjugates [68,69]. Last year, there appeared many reports on the application of AuNCGs to PPT therapy of cancer cells in vitro [70,71] and cancer tumors in vivo [72][73][74][75][76].…”

Section: Au-ag Nanocages (Auncgs)mentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

View full text Add to dashboard Cite

Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

show abstract

“…37,38 In addition, the introduction of Au NCs has enabled Au NCs@ PCN to perform well in photothermal therapy (PTT). 39 In detail, Au NPs@PCN produces high levels of ROS by CDT and PDT under NIR irradiation and kills bacteria by PTT at relatively low temperatures (<57 °C). 40 The combination of multiple modes can avoid the biological toxicity of dosedependent materials and reduce the high-temperature conditions required for PTT sterilization.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing

Zhao

Chang

et al. 2022

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Bacterial infection has been a considerable obstacle for diabetic wound healing. A multifunctional nanoplatform used as nanozyme for bacterial infected diabetic wound is extremely attractive. Therefore, gold nanoclusters modified zirconium-based porphyrin metal–organic frameworks (Au NCs@PCN) were constructed by an in situ growth method. Through SEM, TEM, and EDS mapping, the surface of ellipsoid-shaped particles around 190 nm was observed to be evenly interspersed with 5–8 nm gold nanoclusters. Notably, Au NCs@PCN exhibits excellent performance in exciting ROS generation and photothermal effects. Under near-infrared (NIR) laser irradiation, Au NCs@PCN can be heated to 56.2 °C and produce ROS, showing an effective killing effect on bacteria. Antibacterial studies showed that Au NCs@PCN inhibited MRSA and Ampr E. coli by destroying membrane structure and inducing protein leakage up to 95.3% and 90.6%, respectively. Animal experiments showed that Au NCs@PCN treated diabetic rats had reduced wound coverage to 2.7% within 21 days. The immunoblot analysis showed that proangiogenic and proepithelial cell proliferation factors were expressed significantly up-regulated. These results prove that Au NCs@PCN with photocatalytic and nanozyme activity has a broad application prospect for promoting diabetic infected wound healing.

show abstract

Preparation of photothermal responsive and ROS generative gold nanocages for cancer therapy

Cited by 37 publications

References 47 publications

Plasmonic Gold Nanoisland Film for Bacterial Theranostics

Plasmonic Gold Nanoisland Film for Bacterial Theranostics

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing

Contact Info

Product

Resources

About