Preparation of pH- and ionic-strength responsive biodegradable fumaric acid crosslinked carboxymethyl cellulose

Akar, Emine; Altinisik, Aylin; Seki, Yoldaş

doi:10.1016/j.carbpol.2012.07.043

Cited by 137 publications

(63 citation statements)

References 24 publications

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“…In the majority of cases, Na-CMC-based hydrogels are obtained through chemical cross-linking as a result of reaction with bifunctional cross-linking agents (for example: epichlorohydrin (Chang et al 2010), diepoxy (Rodriguez et al 2003;Kono et al 2013), dicarboxylic acid (Gorgieva and Kokol 2011;Akar et al 2012), aldehydes (Patenaude and Hoare 2012) and polyethylene glycol (Kono 2014). Also, the synthesis of multi-component hydrogels based on carboxymethyl cellulose have been reported (Maswal et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of the degree of substitution on the rheology of sodium carboxymethylcellulose solutions in propylene glycol/water mixtures

2017

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The linear dynamic viscoelastic properties and non-linear transient rheology of sodium carboxymethylcellulose solutions (Na-CMC) in propylene glycol/water mixtures were investigated. Measurements were carried out for the solutions of Na-CMC with three different degrees of substitution (DS), namely 0.62, 0.79, 1.04, and the similar average molecular weight (M w & 250,000 g/mol). The strong synergism between the molecules of Na-CMC with DS of 0.62 and 0.79, and propylene glycol has been observed. The occurrence of the overshoot shear stress and the low loss tangent values indicate the physical cross-linking of the polymer chains. The increase of propylene glycol concentration over 80 wt% and sodium carboxymethylcellulose (DS = 0.7) over 1.6 wt% leads to the formation of a physical cross-link network. The absence of overshoot shear stress and terminal behaviour in SAOS flow of the Na-CMC 1.04 solutions in the PG/water mixture shows that no intermolecular cross-linking of polymer chains occurred in them.

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Section: Introductionmentioning

confidence: 99%

Effect of the degree of substitution on the rheology of sodium carboxymethylcellulose solutions in propylene glycol/water mixtures

2017

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“…Chemical-crosslinking provides CMC gels a more stable three-dimensional network. For example, divinyl sulfone [14], epichlorohydrin [15], aldehydes [16,17], fumaric acid [18] and citric acid [19] have been used as crosslinkers to form CMC and CMC composite gels. Monomers with double bond, such as N-isopropyl acrylamide [20] and partially neutralized acrylic acid/rectorite [21], have been initiated by ammonium persulfate and coupled onto CMC backbones via methylene bisacrylamide (crosslinker).…”

Section: Introductionmentioning

confidence: 99%

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

Ke¹,

Liu²,

Wang

et al. 2014

Express Polym. Lett.

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Abstract. Biocompatible and biodegradable carboxymethyl cellulose (CMC) has been modified with 4-hydroxybenzylamine (CMC-Ph) in order to prepare CMC-based microgels through the horseradish peroxidise/hydrogen peroxide enzymatic reaction. CMC-Ph was identified as a blend, and the amount of the grafted 4-hydroxybenzylamine per 100 units of CMC was between 17 and 23 according to the molecular weight of CMC. Through a special designed co-flowing microfluidic device, CMC-Ph microgels were prepared with the radius from 100 to 500 µm via adjusting the flow rates of the disperse phase and the continuous phase, respectively. The chondrocytic cell line ATDC5 was encapsulated in the CMC-Ph microgels. The cell-laden microgels were cultured for up to 40 days, illustrating the biocompatibility of CMC-Ph and the microfluidic approach through the enzymatic crosslinking reaction primarily. CMC-Ph showed a great promise to encapsulate the cells for further fabrication of the injectable scaffolds.

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“…The cellulose molecule is composed of sequences of β-D-glucopyranose units linked by β-(1,4) glycosidic chemical bonds (Beneke et al 2009). Cellulose and its derivatives are widely used as delivery systems for bioactive compounds, since they are environmentally friendly and can be degraded by many bacteria and fungi present in the air, soil, and water (Raafat et al 2012;Akar et al 2012;Hemvichian et al 2014). …”

Section: Cellulosementioning

confidence: 99%

“…In sorption/ desorption experiments, it was shown that the removal of 2,4-D was improved in the presence of β-CD. Akar et al (2012) synthesized a biodegradable hydrogel using fumaric acid (FA) and sodium carboxymethyl cellulose (SCC), for possible use in formulations for the sustained release of agrochemicals. The hydrogels were characterized using FTIR, SEM, XRD, TGA, exploratory DSC, and AFM.…”

Section: Cyclodextrins As Carrier System To Agrochemicalsmentioning

confidence: 99%

Polysaccharides as safer release systems for agrochemicals

Campos

Oliveira

Fraceto

et al. 2014

Agron. Sustain. Dev.

278

175

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Agrochemicals are used to improve the production of crops. Conventional formulations of agrochemicals can contaminate the environment, in particular in the case of intensive cropping. Hence, there is a need for controlledrelease formulations of agrochemicals such as polysaccharides to reduce pollution and health hazards. Natural polysaccharides are hydrophilic, biodegradable polymers. This article reviews the use of polysaccharides in the form of micro-and nanoparticles, beads and hydrogels. The main points are: (1) slow release formulations minimize environmental impact by reducing agrochemical leaching, volatilization and degradation. For example, 50 % of the encapsulated insecticide chlorpyrifos is released in 5 days, whereas free chlorpyrifos is released in 1 day. (2) Slow release formulations increase the water-holding capacity of soil. (3) Slow release formulations better control weeds in the long run. (4) Polymer-clay formulations store ionic plant nutrients. (5) Polymer hydrogel formulations reduce compaction, erosion, and water run-off. They increase soil permeability and aeration, infiltration rates, and microbial activity, and, in turn, plant performance. In conclusion, polysaccharide formulations can be used for safer use of agrochemicals.

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Preparation of pH- and ionic-strength responsive biodegradable fumaric acid crosslinked carboxymethyl cellulose

Cited by 137 publications

References 24 publications

Effect of the degree of substitution on the rheology of sodium carboxymethylcellulose solutions in propylene glycol/water mixtures

Effect of the degree of substitution on the rheology of sodium carboxymethylcellulose solutions in propylene glycol/water mixtures

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

Polysaccharides as safer release systems for agrochemicals

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