Preparation of oriented collagen fiber scaffolds and its application in bone tissue engineering

Ma, Chunyang; Wang, Hetong; Chi, Yongjie; Wang, Yanling; Jiang, Le; Xu, Nan; Wu, Qiong; Feng, Qingling; Sun, Xiaodan

doi:10.1016/j.apmt.2020.100902

Cited by 42 publications

(40 citation statements)

References 106 publications

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“…Although bone is constantly remodeled in physiological conditions and presents a strong regenerative capacity, in case of extensive traumas, repairing processes are not able to fully regenerate the injured tissue and surgical interventions are needed. Actually, autograft is the gold standard for repairing defective tissue, but it may lead to donor tissue degeneration and dysfunction (Ma et al, 2021). However, the limited access to autologous bone, donor site morbidity, surgical complications, fitting irregular defect difficulties, as well as inconsistent repair limited its execution (Dewey et al, 2021).…”

Section: Bonementioning

confidence: 99%

“…However, the limited access to autologous bone, donor site morbidity, surgical complications, fitting irregular defect difficulties, as well as inconsistent repair limited its execution (Dewey et al, 2021). On the other side, allotransplantation can cause immune rejection (Ma et al, 2021). Thus, the high number of shortcomings of current treatments headed research for tissue engineering solutions.…”

Section: Bonementioning

confidence: 99%

“…The arrangement of collagen fibers in bone is much more complex than in other tissues, and it is very difficult to achieve ECM-like bottom-up temporal bone substitutes. To this, oriented collagen fiber scaffolds were not widely investigated for use in bone tissue engineering (Ma et al, 2021). Thus, the challenging goal is to develop scaffolds able to mimic the microenvironment of native bone in vivo and to: (i) provide a temporary mechanical support; (ii) have an appropriate porous architecture to promote bone cell migration and differentiation into the scaffold; (iii) encourage osteoinduction; (iv) and enhance osteointegration with the host tissue.…”

Section: Bonementioning

confidence: 99%

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Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration

Salvatore

Gallo

Natali

et al. 2021

Front. Bioeng. Biotechnol.

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Biological materials found in living organisms, many of which are proteins, feature a complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in the mammalian body, provides a striking example of such a hierarchical material, with peculiar architectural features ranging from the amino acid sequence at the nanoscale (primary structure) up to the assembly of fibrils (quaternary structure) and fibers, with lengths of the order of microns. Collagen plays a dominant role in maintaining the biological and structural integrity of various tissues and organs, such as bone, skin, tendons, blood vessels, and cartilage. Thus, “artificial” collagen-based fibrous assemblies, endowed with appropriate structural properties, represent ideal substrates for the development of devices for tissue engineering applications. In recent years, with the ultimate goal of developing three-dimensional scaffolds with optimal bioactivity able to promote both regeneration and functional recovery of a damaged tissue, numerous studies focused on the capability to finely modulate the scaffold architecture at the microscale and the nanoscale in order to closely mimic the hierarchical features of the extracellular matrix and, in particular, the natural patterning of collagen. All of these studies clearly show that the accurate characterization of the collagen structure at the submolecular and supramolecular levels is pivotal to the understanding of the relationships between the nanostructural/microstructural properties of the fabricated scaffold and its macroscopic performance. Several studies also demonstrate that the selected processing, including any crosslinking and/or sterilization treatments, can strongly affect the architecture of collagen at various length scales. The aim of this review is to highlight the most recent findings on the development of collagen-based scaffolds with optimized properties for tissue engineering. The optimization of the scaffolds is particularly related to the modulation of the collagen architecture, which, in turn, impacts on the achieved bioactivity.

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Section: Bonementioning

confidence: 99%

Section: Bonementioning

confidence: 99%

Section: Bonementioning

confidence: 99%

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Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration

Salvatore

Gallo

Natali

et al. 2021

Front. Bioeng. Biotechnol.

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“…A good balance between inflammation and ECM remodeling is essential to maintain homeostasis and to restore essential functions after tissue damage [26]. Collagens provide tensile strength, regulate cell adhesion, support chemotaxis and migration, and direct tissue development in tissue engineering process [29].…”

Section: 1collagen For Tissue Regenerationmentioning

confidence: 99%

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

Ebhodaghe¹,

Fattahi²,

Ndibe³

et al. 2021

Preprint

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There is need to address the challenges of organ shortage, through development of tissues and organs with alternatives to those of the allograft-kind. This illustrates the quest behind novel biofabrication strategies such as 3D bio-printing, which is necessary to create artificial multi-cellular tissues/organs. Several findings have been reported in this review. First, the role of ECM components in tissue regenerative medicine is presented. Different ECM components such as collagen, gelatin, elastin, fibronectin, laminins and glycosaminoglycans are concisely examined for their tissue regenerative medicine applications. Next, current state of research on extrusion-based 3D bio-printing techniques and their limitations are reviewed. For example, we show that cell viability is still a challenge with extrusion, while the use of natural polymers such as collagen in improving composites’ mechanical properties is limited. Lastly, we examine unresolved research questions necessary to advance the present state of research in the field.

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“…Besides, collagen participates in numerous physiological interactions through its specific cell-binding sites, where the cell attachment, proliferation, migration, growth, and differentiation are the most significant [ 9 , 10 ]. Thus, collagen scaffolds have been used for tissue engineering due to their hemostatic, low antigenic, biodegradable, and biocompatible properties [ 11 , 12 ]. However, the resulting scaffolds offer poor mechanical properties and structural stability [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

et al. 2021

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Native collagen doughs were processed using a syringe-based extrusion 3D printer to obtain collagen scaffolds. Before processing, the rheological properties of the doughs were analyzed to determine the optimal 3D printing conditions. Samples showed a high shear-thinning behavior, reported beneficial in the 3D printing process. In addition, tetrahydrocurcumin (THC) was incorporated into the dough formulation and its effect on collagen structure, as well as the resulting scaffold’s suitability for wound healing applications, were assessed. The denaturation peak observed by differential scanning calorimetry (DSC), along with the images of the scaffolds’ surfaces assessed using scanning electron microscopy (SEM), showed that the fibrillar structure of collagen was maintained. These outcomes were correlated with X-ray diffraction (XRD) results, which showed an increase of the lateral packaging of collagen chains was observed in the samples with a THC content up to 4%, while a higher content of THC considerably decreased the structural order of collagen. Furthermore, physical interactions between collagen and THC molecules were observed using Fourier transform infrared (FTIR) spectroscopy. Additionally, all samples showed swelling and a controlled release of THC. These results along with the mucoadhesive properties of collagen suggested the potential of these THC–collagen scaffolds as sustained THC delivery systems.

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Preparation of oriented collagen fiber scaffolds and its application in bone tissue engineering

Cited by 42 publications

References 106 publications

Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration

Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

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