Preparation of Orally Disintegrating Tablets Containing Powdered Tea Leaves with Enriched Levels of Bioactive Compounds by Means of Microwave Irradiation Technique

Abstract

In the present study, a microwave treatment process has been applied to prepare orally disintegrating tablets (ODTs) containing powdered tea leaves with enriched levels of the anti-inflammatory compounds such as chafuroside A (CFA) and chafuroside B (CFB). The use of distilled water as the adsorbed and granulation solvents in this preparation process afforded tablets with a long disintegration time (more than 120 s). The CFA and CFB contents of these tablets did not also change after 4 min of microwave irradiation due to the tablet temperature, which only increased to 100°C. In contrast, the tablet temperature increased up to 140°C after 3 min of microwave irradiation when a 1.68 M Na 2 HPO 4 solution instead of distilled water. Notably, the disintegration time of these tablets was considerably improved (less than 20 s) compared with the microwaveuntreated tablets, and there were 7-and 11-fold increases in their CFA and CFB contents. In addition, the operational conditions for the preparation of the tablets were optimized by face-centered composite design based on the following criteria: tablet hardness greater than 13 N, disintegration time less than 30 s and friability less than 0.5%. The requirements translated into X 1 (the amount of granulation solvent), X 2 (tableting pressure) and X 3 (content of the powdered tea leaves) values of 45%, 0.43 kN and 32%, respectively, and the ODTs containing powdered tea leaves prepared under these optimized conditions were found to show excellent tablet properties and contain enriched levels of CFA and CFB.

Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care

“…All formulations had hardness values of over 13 N (Fig. 2B), which is sufficient hardness for a 5-mm diameter tablet (Tanaka et al, 2016). This is because the excipient d -mannitol melts at 168 °C and forms strong particle-to-particle bonds during microwave irradiation.…”

“…ODTTs were prepared using an established method with a slight modification (Tanaka et al, 2016). Oolong tea leaves were ground using a standard tea grinder (Teafine Mutow, Shizuoka, Japan).…”

“…In addition, we developed orally disintegrating tea tablets (ODTTs) containing powdered tea leaves. These ODTTs disintegrated within the oral cavity within 30 s (Tanaka et al, 2016). In a preliminary evaluation of antibacterial activity against S. mutans , an ODTT extract greatly inhibited bacterial growth compared with artificial saliva.…”

Recent Formulation Advances and Therapeutic Usefulness of Orally Disintegrating Tablets (ODTs)

“…It was observed that the disintegration time of these tablets was considerably improved (less than 20 s) compared with the microwave-untreated tablets, and there were 7- and 11-fold increases in their CFA and CFB contents. Hardness and friability characteristics of the microwave treated tablets were found to be acceptable [ 23 ]. Lamotrigine ODTs were formulated using microwave-assisted development of ODTs based on simple direct compression tableting technology.…”

Crystal Structures of Flavone <i>C</i>-Glycosides from Oolong Tea Leaves: Chafuroside A Dihydrate and Chafuroside B Monohydrate

“…Formulations of chafurosides have been designed to extend their therapeutic applications. Orally disintegrating tablets containing powdered tea leaves have been developed using a microwave treatment method, 10) which increases the contents of chafurosides A and B by promoting their formation from precursor molecules while retaining immediate disintegration properties and tablet hardness. 11) A self-assembled micellar formulation of chafuroside A with improved solubility and, as a result, enhanced antiinflammatory activity, was reported.…”