Preparation of octacalcium phosphate from calcium carbonate powder

Fedotov, A. Yu.; Komlev, V. S.; Teterina, A. Yu.; Сиротинкин, В. П.; Шамрай, В. Ф.; Фадеева, И. В.; Баринов, С. М.

doi:10.1134/s0020168513110058

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…The analysis of the samples stored in physiological solution for different periods of time up to 3 days puts into evidence the different roles played by the additives and by temperature. On comparing the results obtained when the hydrolysis is carried out at 37 °C with those at 60 °C, it is evident that increasing the temperature accelerates the transformation of DCPD into thermodynamically more stable phases, in agreement with previous data [21,22].…”

Section: Resultssupporting

confidence: 90%

Role of Aspartic and Polyaspartic Acid on the Synthesis and Hydrolysis of Brushite

Rubini

Boanini

Bigi

2019

JFB

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Dicalcium phosphate dihydrate (DCPD) is one of the mineral phases indicated as possible precursors of biological apatites and it is widely employed in the preparation of calcium phosphate bone cements. Herein, we investigated the possibility to functionalize DCPD with aspartic acid (ASP) and poly-aspartic acid (PASP), as models of the acidic macromolecules of biomineralized tissues, and studied their influence on DCPD hydrolysis. To this aim, the synthesis of DCPD was performed in aqueous solution in the presence of increasing concentrations of PASP and ASP, whereas the hydrolysis reaction was carried out in physiological solution up to three days. The results indicate that it is possible to prepare DCPD functionalized with PASP up to a polyelectrolyte content of about 2.3 wt%. The increase of PASP content induces crystal aggregation, reduction of the yield of the reaction and of the thermal stability of the synthesized DCPD. Moreover, DCPD samples functionalized with PASP display a slower hydrolysis than pure DCPD. On the other hand, in the explored range of concentrations (up to 10 mM) ASP is not incorporated into DCPD and does not influence its crystallization nor its hydrolysis. At variance, when present in the hydrolysis solution, ASP, and even more PASP, delays the conversion into the more stable phases, octacalcium phosphate and/or hydroxyapatite. The greater influence of PASP on the synthesis and hydrolysis of DCPD can be ascribed to the cooperative action of the carboxylate groups and to its good fit with DCPD structure.

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Section: Resultssupporting

confidence: 90%

Role of Aspartic and Polyaspartic Acid on the Synthesis and Hydrolysis of Brushite

Rubini

Boanini

Bigi

2019

JFB

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“…Non‐xl Fe phosphate was purchased (Sigma‐Aldrich Corp.), and Ca phosphate (brushite or CaHPO 4 · 2H 2 O) was synthesized by reacting dicalcium phosphate with acetic acid and ammonium bicarbonate at pH 6.5 for 5 h at 37 °C, following the combined methods of Fedotov et al. (2013) and Arellano‐Jiménez, García‐García, and Reyes‐Gasga (2009). The precipitates were washed with CO 2 –free water, dried to a constant weight (60 °C), ground in a ball mill to pass a 53‐μm mesh, and stored in a dessicator at ambient temperature until use.…”

Section: Methodsmentioning

confidence: 99%

Phosphate solubilization from adsorbents and precipitates by different AVAIL polymers

Doydora

Thompson

Hesterberg

2020

Soil Science Soc of Amer J

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Less than 40% of phosphate fertilizer applied to soils is typically taken up by the intended crop within the year of application because of strong soil retention. AVAIL polymers are fertilizer additives that were commercially developed to enhance availability of fertilizer phosphate. Knowledge of underlying mechanisms of phosphate solubilization would help to optimize the effectiveness of these polymers for different soils. This study compared different types and levels of AVAIL polymers in solubilizing (ad)sorbed and precipitated phosphate to gain insights into the mechanisms involved. Varying inputs of four newer forms of polymers and the original AVAIL (Original) were co‐reacted with one level of phosphate (ad)sorbed on ferrihydrite or noncrystalline Al hydroxide in batch (ad)sorption experiments or with Fe and Ca phosphate precipitates in dissolution experiments. Dissolved phosphate increased with increasing levels of co‐added polymers reacted with (ad)sorbents or phosphate precipitates. Across input levels evaluated, the Original AVAIL generally solubilized more phosphate from ferrihydrite than any of the new formulations. The Original and the new Liquid 2 formulation equally solubilized the greatest phosphate from Fe phosphate, whereas Liquid 2 solubilized more phosphate from Al hydroxide and Ca phosphate. (Ad)sorption and dissolution results implied competitive (ad)sorption and complexometric dissolution as key mechanisms. Our results suggest that the effectiveness of AVAIL polymers in soils depends on the level of added polymer charge relative to phosphate adsorption capacities or the types of phosphate minerals present.

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“…Calcium carbonate granules were transformed to octacalcium phosphate according to the route described elsewhere [11,35]. Briefly, aqueous solution was prepared by dissolving of 115 g of NH 4 H 2 PO 4 in 500 mL of distilled water at room temperature at pH 4.1 ± 0.1.…”

Section: Preparation and Characterization Of Ocp Ceramic Granulesmentioning

confidence: 99%

Octacalcium phosphate ceramics combined with gingiva-derived stromal cells for engineered functional bone grafts

et al. 2014

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Biocompatible ceramic fillers are capable of sustaining bone formation in the proper environment. The major drawback of these scaffolding materials is the absence of osteoinductivity. To overcome this limitation, bioengineered scaffolds combine osteoconductive components (biomaterials) with osteogenic features such as cells and growth factors. The bone marrow mesenchymal stromal cells (BMMSCs) and the β-tricalcium phosphate (β-TCP) are well-known and characterized in this regard. The present study was conducted to compare the properties of novel octacalcium phosphate ceramic (OCP) granules with β-TCP (Cerasorb(®)), gingiva-derived mesenchymal stromal cells (GMSCs) properties with the BMMSCs and osteogenic and angiogenic properties of a bioengineered composite based on OCP granules and the GMSCs. This study demonstrates that GMSCs and BMMSСs have a similar osteogenic capacity. The usage of OCP ceramic granules in combination with BMMSCs/GMSCs significantly affects the osteo- and angiogenesis in bone grafts of ectopic models.

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Preparation of octacalcium phosphate from calcium carbonate powder

Cited by 9 publications

References 4 publications

Role of Aspartic and Polyaspartic Acid on the Synthesis and Hydrolysis of Brushite

Role of Aspartic and Polyaspartic Acid on the Synthesis and Hydrolysis of Brushite

Phosphate solubilization from adsorbents and precipitates by different AVAIL polymers

Octacalcium phosphate ceramics combined with gingiva-derived stromal cells for engineered functional bone grafts

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