Preparation of novel pyrazole substituted triazole libraries and estimation of their biological activity

Abstract

We have constructed a new library of 1,2,3-triazole tethered pyrazole derivatives (6 a-h & 7 a-h) from propargyl alcohol through simultaneous click process, oxidation, condensation, and rearrangement under mild reaction conditions. The final products were obtained in moderate to good yields. All the compound structures were characterized by analytical and spectral ( 1 H NMR, 13 C NMR & HRMS) studies. Furthermore, the evaluation of biological activity of newly synthesized molecules was done against three human cancer cell lines, such as HeLa (Human cervical cancer), A549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma). Compound 7 e has showed good anti-proliferation activity with HeLa (IC 50 0.13 � 0.02 μM), MCF-7 (IC 50 2.7 � 0.3 μM), while compounds 6 a and 6 g gave favourable anti-proliferation against above three human cancer cell lines, compared with the standard drug Doxorubicin.

Greener and Highly Efficient Synthesis, In Silico ADMET and Molecular Docking Studies of Potent Antimicrobial Thiophene Clubbed Pyrazole‐1,2,3‐Triazole Hybrids

“…Moreover, compounds bearing thiophene in their structure have been found to possess potency towards a variety of biological activities such as antimicrobial, anticancer, anti‐inflammatory, anticonvulsant, antidiabetic, antiproliferative, and analgesic activities [27–35] . As per findings in the literature, pyrazole‐1,2,3‐triazole hybrids are potent pharmacologically active molecules [1,9,12,13,36–38] . Even more, the pyrazole, thiophene, and 1,2,3‐triazole rings have been found in various biologically utilized well‐known synthetic drugs for the treatment of a variety of ailments (Figure 1).…”

“…[4] Because of these facts, hybrids of pyrazole, thiophene, and 1,2,3-triazole are the main focus of this investigation because these heterocycles exhibit a variety of pharmacological activities. In various works of literature, the pyrazole nucleus has demonstrated a variety of biological activities such as antimicrobial, [1,2,[5][6][7][8][9] antitubercular, antibiofilm, [5] antimalarial, [6] anticancer, [7][8][9][10][11][12] antioxidant, [11][12][13] anti-inflammatory and analgesic [14] activities. According to the currently reported literature, the pyrazole ring exhibited activity in antioxidant, pancreatic lipase, and GABA-AT inhibitory functions, with excellent molecular docking and ADMET profiles.…”

“…[27][28][29][30][31][32][33][34][35] As per findings in the literature, pyrazole-1,2,3-triazole hybrids are potent pharmacologically active molecules. [1,9,12,13,[36][37][38] Even more, the pyrazole, thiophene, and 1,2,3-triazole rings have been found in various biologically utilized well-known synthetic drugs for the treatment of a variety of ailments (Figure 1).…”