“…They deduced that a 3,4,5 -trimethoxy phenyl and a 4-methoxy-3-Xsubstituted phenyl system, separated by two atom bridge and in cis-disposition, are the common structural characteristics for combretastatins to be active (X=H, OH, NH 2 , and their amino acid, phosphate, or other derivatives for solubilizing purposes). These structural requisites have been attained in derivatives and analogs of diverse type such as cis-olefins [6,25,26,36,52], sulfonamides [53][54][55][56], sulfonates [57,58], amine or amide derivatives [27,[59][60][61], ethers [62], cyclopentanes, or cyclopentenes [63,64], naphthalenes [29,65,66], phosphates [18,21,[67][68][69], azides [70], aminobenzophenones [71], carboxamide, or carbamate [72], diarylmaleimides [73] and heterocycles ( pyrazole, thiazole, triazole, or tetrazole [74], isoxazole, oxazole or oxadiazole [28,31,75,76], imidazole, or pyrazole [28,77], thiophenes [78,79], furans, furazans, furanones, or dioxolanes [80][81][82][83]…”