Preparation of Nanoemulsions of Mentha piperita Essential Oil and Investigation of Their Cytotoxic Effect on Human Breast Cancer Lines

Abedinpour, Niloufar; Ghanbariasad, Ali; Taghinezhad, Ali; Osanloo, Mahmoud

doi:10.1007/s12668-021-00827-4

Cited by 35 publications

(12 citation statements)

References 34 publications

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“…The samples' particle size distribution (SPAN) was also calculated as d90-d10/d50, where d is diameter and 10, 50, and 90 are percentages of particles with lower sizes than these values. SPAN values less than 1 confirm narrow particle size distribution [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors

Sanei-Dehkordi

Moemenbellah‐Fard

Saffari

et al. 2022

BMC Complement Med Ther

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Background Mosquito-borne diseases such as malaria and encephalitis are still the cause of several hundred thousand deaths annually. The excessive use of chemical insecticides for transmission control has led to environmental pollution and widespread resistance in mosquitoes. Botanical insecticides' efficacies improvement has thus received considerable attention recently. Methods The larvicidal effects of three essential oils from the Citrus family and limonene (their major ingredient) were first investigated against malaria and filariasis mosquito vectors. An attempt was then made to improve their efficacies by preparing nanoliposomes containing each of them. Results The larvicidal effect of nanoformulated forms was more effective than non-formulated states. Nanoliposomes containing Citrus aurantium essential oil with a particle size of 52 ± 4 nm showed the best larvicidal activity (LC50 and LC90 values) against Anopheles stephensi (6.63 and 12.29 µg/mL) and Culex quinquefasciatus (4.9 and 16.4 µg/mL). Conclusion Due to the green constituents and high efficacy of nanoliposomes containing C. aurantium essential oil, it could be considered for further investigation against other mosquitoes’ populations and field trials.

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Section: Methodsmentioning

confidence: 99%

Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors

Sanei-Dehkordi

Moemenbellah‐Fard

Saffari

et al. 2022

BMC Complement Med Ther

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“…In the current study, nanoemulsions containing cinnamon and clove EOs were prepared; as obtained droplet sizes were lower than 200 nm, their nanoscale sizes were confirmed. Moreover, a droplet size distribution of less than 1 confirms narrow size distribution and single sharp peaks referred to as monodisperse systems [ 26 ]. The low-Energy or spontaneous method is common for preparing EO-based nanoemulsions and preventing evaporating volatile compounds in EOs [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Formulating of EOs as nanoformulations is a promising approach for increasing their efficacy [ 25 , 26 ]. Among the nanoformulations, nanoemulsions are more considered due to their relatively fewer side effects, bioavailability, and simpler preparation methods [ 27 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Esmaeili

Zahmatkeshan

Yousefpoor

et al. 2022

BMC Complement Med Ther

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Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.

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“…A polymeric micelle is formed primarily when the hydrophobic section of a block copolymer is forced into the aqueous phase, while the hydrophilic portion faces outward to form a shell. Nanoemulsions are another kind of nanocarriers that are being explored as an anticancer drug delivery system in MDR [50]. Most of the nanoemulsions are oil in water types, in which oil droplets are dispersed in the continuous phase (water) at the size of about 10-100 nm.…”

Section: Nanotechnology-mediated Drug Delivery In Breast Cancermentioning

confidence: 99%

Receptor-Mediated Targeted Delivery of Surface-ModifiedNanomedicine in Breast Cancer: Recent Update and Challenges

et al. 2021

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Breast cancer therapeutic intervention continues to be ambiguous owing to the lack of strategies for targeted transport and receptor-mediated uptake of drugs by cancer cells. In addition to this, sporadic tumor microenvironment, prominent restrictions with conventional chemotherapy, and multidrug-resistant mechanisms of breast cancer cells possess a big challenge to even otherwise optimal and efficacious breast cancer treatment strategies. Surface-modified nanomedicines can expedite the cellular uptake and delivery of drug-loaded nanoparticulate constructs through binding with specific receptors overexpressed aberrantly on the tumor cell. The present review elucidates the interesting yet challenging concept of targeted delivery approaches by exploiting different types of nanoparticulate systems with multiple targeting ligands to target overexpressed receptors of breast cancer cells. The therapeutic efficacy of these novel approaches in preclinical models is also comprehensively discussed in this review. It is concluded from critical analysis of related literature that insight into the translational gap between laboratories and clinical settings would provide the possible future directions to plug the loopholes in the process of development of these receptor-targeted nanomedicines for the treatment of breast cancer.

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Preparation of Nanoemulsions of Mentha piperita Essential Oil and Investigation of Their Cytotoxic Effect on Human Breast Cancer Lines

Cited by 35 publications

References 34 publications

Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors

Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Receptor-Mediated Targeted Delivery of Surface-ModifiedNanomedicine in Breast Cancer: Recent Update and Challenges

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