Preparation of N,N′-Dimethyl-and N,N′-Diethylsulfamide

Bermann, M.; Wazer, John R. Van

doi:10.1055/s-1972-21942

Cited by 14 publications

(3 citation statements)

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“…Symmetric N,N 0 -disubstituted sulfamides and tetra-substituted sulfamides were prepared in concordance with the typical procedures by condensation of an excess of amine with sulfuryl chloride (compounds 7 to 15). [24][25][26][27][28][29] Similarly, N,N 0 -di-substituted aminoacid derived sulfamides 16-18 were prepared by reaction of the corresponding salts of amino esters with sulfuryl chloride in presence of triethylamine. 30 Mono-substituted sulfamides (compounds 3-4) were synthesized following the standard method that involves the preparation of N-alkoxycarbonyl sulfamides as intermediates of the reaction.…”

Section: Synthesis Of Sulfamides and Sulfamatesmentioning

confidence: 99%

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

Gavernet

Funes

Palestro

et al. 2013

Bioorganic & Medicinal Chemistry

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A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki <1μm) and selectivity: some aromatic sulfamides are active against CA I, CA II and/or CA VII; while they are less active in CA XII and CA XIV. On the other hand, bulky sulfamides are selective to CA VII. To understand the origin of the different inhibitory activity against each isozyme we used molecular modeling techniques such as docking and molecular dynamic simulations.

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Section: Synthesis Of Sulfamides and Sulfamatesmentioning

confidence: 99%

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

Gavernet

Funes

Palestro

et al. 2013

Bioorganic & Medicinal Chemistry

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“…Realistically, as Bermann notes, the issue of recognition and preclusive effect in that sort of case is only likely to arise if a US class action is perceived to have yielded an unsatisfactory level of damages to foreign class members. From the defendant's perspective though, if some uninvolved ECMs consider that they could do better before an English court – and if the rules of English private international law permit them to re‐litigate – then this is surely a grave disincentive to any defendant settling with them. Defendants enter class actions settlements precisely to ‘purchase global peace’.…”

Section: Setting the Contextmentioning

confidence: 99%

The Recognition, and Res Judicata Effect, of a United States Class Actions Judgment in England: A Rebuttal of Vivendi

Mulheron

2012

Modern Law Review

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United States' courts have proven willing to certify multi‐jurisdictional class actions which purport to adjudicate the claims of both American and foreign (i.e., non‐US‐domiciled) class members. This article contends, however, that a class actions judgment/settlement issued by a US court would not be recognised, and would not be given preclusive effect, in England, should absent English class members wish to re‐litigate the same grievance before an English court. Specifically, it is argued that two separate preconditions for such recognition and preclusive effect would fail, viz, a US court would usually lack the requisite ‘personal jurisdiction’ over absent English class members; and the necessary ‘identity of parties’ would be absent. The article seeks to anticipate the appropriate answer to a conundrum which is certain to arise for future English judicial consideration, whilst acknowledging the uneasy fit which currently exists between English private international law and multi‐jurisdictional class actions.

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“…Py, which attacks the sulfur atom of the sulfuryl moiety, should be further replaced by the corresponding amine (Scheme 1). However, Bermann et al [18], and subsequently other researchers [6,10,19] have successfully obtained N,N¢-substituted sulfamides with no Py participating in the reaction (Scheme 2)…”

Section: Synthetic Routesmentioning

confidence: 99%

Synthesis of anticonvulsant sulfamides. Theoretical study of the related mechanism

Gavernet

Cisneros

Bruno-Blanch

et al. 2003

Theoretical Chemistry Accounts: Theory, Computation, and Modeli

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A theoretical study of the mechanisms associated with the synthesis of anticonvulsant symmetric N,N¢-substituted sulfamides is presented. Two possible synthetic routes are compared, which mainly differ in the use of pyridine as a nucleophilic agent in the reaction mechanism. Geometry optimization techniques and transition-state detection at the B3LYP/6-31G** level, modeling the solvent by means of an isodensity polarizable continuum approach, allow the most suitable method for the experimental process to be discerned.

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Preparation of N,N′-Dimethyl-and N,N′-Diethylsulfamide

Cited by 14 publications

References 0 publications

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

The Recognition, and Res Judicata Effect, of a United States Class Actions Judgment in England: A Rebuttal of Vivendi

Synthesis of anticonvulsant sulfamides. Theoretical study of the related mechanism

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