Preparation of multifunctional drug sustained-release system by atomic layer deposition of ZnO in mesoporous titania coating

Wu, Xinghai; Yao, Litao; Al-Baadani, Mohammed A.; Ping, Linchao; Wu, Shuyi; Al-Bishari, Abdullrahman M.; HiiRuYie, Kendrick; Deng, Zhennan; Liu, Jinsong; Shen, Xinkun

doi:10.1016/j.ceramint.2019.12.201

Cited by 10 publications

(13 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mesoporous titanium modified with zinc oxide can enhance osteogenic differentiation. [18] The doping of Zn 2+ onto the surface of sulfonated polyetheretherketone significantly enhanced the osteogenic differentiation capability of MSCs, leading to improved osteointegration between the biomaterials and bone tissue. [19] Zinc substitution in hydroxyapatite coating moderately promoted MSC differentiation into osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation

Ren

Liang

Dong

et al. 2022

Small

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) have been recognized as one of the most promising pharmaceutical multipotent cells, and a key step for their wide application is to safely and efficiently regulate their activities. Various methods have been proposed to regulate the directional differentiation of MSCs during tissue regeneration, such as nanoparticles and metal ions. Herein, nanoscale zeolitic imidazolate framework‐8 (ZIF‐8), a Zn‐based metal–organic framework, is modified to direct MSCs toward an osteoblast lineage. Specifically, ZIF‐8 nanoparticles are encapsulated using stem cell membranes (SCMs) to mimic natural molecules and improve the biocompatibility and targeted ability toward MSCs. SCM/ZIF‐8 nanoparticles adjust the sustained release of Zn2+, and promote their specific internalization toward MSCs. The internalized SCM/ZIF‐8 nanoparticles show excellent biocompatibility, and increase MSCs’ osteogenic potentials. Moreover, RNA‐sequencing results elucidate that the activated cyclic adenosine 3,5‐monophosphate (cAMP)‐PKA‐CREB signaling pathway can be dominant in accelerating osteogenic differentiation. In vivo, SCM/ZIF‐8 nanoparticles greatly promote the formation of new bone tissue in the femoral bone defect detected by 3D micro‐CT, hematoxylin and eosin staining, and Masson staining after 4 weeks. Overall, the SCM‐derived ZIF‐8 nanostructures achieve the superior targeting ability, biocompatibility, and enhanced osteogenesis, providing a constructive design for tissue repair.

show abstract

Section: Introductionmentioning

confidence: 99%

Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation

Ren

Liang

Dong

et al. 2022

Small

View full text Add to dashboard Cite

show abstract

“…It is noteworthy that the PTX@ANG/FA-NPs were more easily taken up by tumor cells, confirming their stronger apoptotic effects in term of quantitative analysis Figure (c,d). This will also help researchers to explore the functional role of the prepared probe, which is far better as compared to results in literature reports. − …”

Section: Resultsmentioning

confidence: 84%

Interpreting the Therapeutic Efficiency of Multifunctional Hybrid Nanostructure against Glioblastoma

You

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Glioblastoma is considered the most fatal malignant brain tumor that starts from the central nervous system (CNS), where the blood−brain barrier (BBB) remains the biggest challenge for active targeting of drugs in malignant brain tumor. Thereby, we have designed a paclitaxel PTX@ANG/FA-NPs hybrid novel nanodrug delivery system that can overcome the clinical BBB. The structural and morphological characterization of PTX@ ANG/FA-NPs confirmed successful synthesis of nanomicelles with the size range of about 160 to 170 nm. The overall repressive effect of PTX@ANG/FA-NPs on human glioblastoma U251 cells was 1.2-times that of PTX alone. In vitro cellular uptake assay also demonstrated that the dual-targeted nanoparticles (NPs) were more easily taken up by glioblastoma U251 cells. Although the antiglioblastoma activity was confirmed by cell migration assay, apoptosis assay, and cellular uptake assay, the absorption was studied by in vivo fluorescence imaging and brain distribution. The synthesized PTX@ANG/FA-NPs probe significantly inhibited the migration of U251 within the cells and promoted the apoptosis process. Moreover, the RhB@ ANG/FA-NPs and PTX@ANG/FA-NPs showed higher accumulating potential at sites of tumor BBB disruption. The novel nanodrug delivery system mediated enhanced distribution of drugs at the targeted site for therapeutics efficacies against glioblastomas across the BBB.

show abstract

“…In the same way, the ZnO seed layer was also prepared by atomic layer deposition (ALD), which has uniform and narrow particles with an average size of 20 nm, and the thickness of this layer was approximately 40 nm [ 65 ]. However, as the cycling number gradually increases from 0 to 50, the biocompatibility of the material shows a tendency to ramp up and down, indicating the toxicity of nano-ZnO sheets with excessive thickness [ 48 ]. Therefore, the control of cycle parameters in ALD technology is a decisive means to affect the biological properties of materials.…”

Section: Fabrication Of Nano-zno Modified Ti Materials and Their Biosafe Propertiesmentioning

confidence: 99%

“…Notably, as an amphoteric metal oxide, ZnO has attracted wide attention for its strong and broad-spectrum antimicrobial, antitumor, low toxicity, and various other properties [ 46 – 48 ]. In particular, nanoscale ZnO particles (nano-ZnO), which have been approved for human use by the U.S. Food and Drug Administration (USFDA), exhibit attractive antibacterial properties because Zn 2+ and reactive oxygen species (ROS) are released by nano-ZnO [ 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

“…Also, zinc is an essential trace element in cell development, DNA synthesis, enzyme activity, and biomineralization [ 51 ]. A proper amount of zinc on the surface of biomaterials has been confirmed to stimulate bone cells and induce a range of in vivo behaviors, e.g., adhesion, spreading, proliferation, osteogenic differentiation, osteogenesis, and mineralization [ 48 , 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Wang

et al. 2021

J Nanobiotechnol

View full text Add to dashboard Cite

Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed. Graphical Abstract

show abstract

Preparation of multifunctional drug sustained-release system by atomic layer deposition of ZnO in mesoporous titania coating

Cited by 10 publications

References 57 publications

Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation

Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation

Interpreting the Therapeutic Efficiency of Multifunctional Hybrid Nanostructure against Glioblastoma

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Contact Info

Product

Resources

About