Preparation of mucoadhesive microspheres containing antimicrobial agents for eradication of

“…Thus frequent dosing is required. 5,6 Gastroretentive drug delivery systems favor prolonged drug release in the stomach. 7 Unlike traditional controlled release formulations, they bypass the gastric emptying process which interferes with drug delivery to the upper GIT.…”

Section: Introductionmentioning

confidence: 99%

Development of Floating-Mucoadhesive Microsphere for Site Specific Release of Metronidazole

Amin¹,

Ahmed²,

Mannan³

2016

Adv Pharm Bull

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“…They have been formulated as mucoadhesive particles or tablets (1)(2)(3). There has been adequate coverage of the microspheres drug delivery system (4,5). Polymeric microparticles represent an interesting drug delivery strategy.…”

mentioning

confidence: 99%

Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation

Attama

Nwabunze²

2007

Acta Pharmaceutica

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Microspheres refer to the micro-particulate polymer based drug delivery system with an average particle size larger than 1 µm. Microsphere carrier systems made from naturally occurring biodegradable polymers have attracted considerable attention for several 161 Acta Pharm. 57 (2007) An investigation into the suitability of mucuna gum microspheres for oral delivery of glibenclamide is presented. Mucuna gum microspheres were formulated under different conditions of polymer concentration and crosslinking time at constant speed. The formulated microspheres were thereafter loaded with glibenclamide by the remote loading process. The microspheres were evaluated according to particle size, yield, loading efficiency and swelling.In vitro release of glibenclamide from the microspheres was studied in simulated intestinal fluid (SIF, pH 7.4). The release data was fitted into two release models to investigate the mechanism of glibenclamide release from the microspheres. All the microspheres showed good swelling characteristics in distilled water. The investigation revealed that the microspheres produced with 5% (m/V) mucuna gum with a crosslinking time of 5 h had the optimum prolonged release pattern. The microspheres produced using 10% (m/V) mucuna gum with a crosslinking time of 1 h had the highest delayed release of the incorporated drug, whereas those without crosslinking had the fastest release. The Ritger-Peppas case I transport model appeared to have adequately described the release process as about 54% of the batches of microspheres conformed to this model. This implies that a formulation of glibenclamide-loaded mucuna gum microspheres is likely to offer a reliable means of delivering glibenclamide by the oral route.

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Preparation of mucoadhesive microspheres containing antimicrobial agents for eradication of

Cited by 28 publications

References 13 publications

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

Development of Floating-Mucoadhesive Microsphere for Site Specific Release of Metronidazole

Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation

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