Preparation of monodisperse large-porous silica microspheres with polymer microspheres as the templates for protein separation

Xia, Hongjun; Wan, Guangping; Yang, Fan; Wang, Jianshan; Bai, Qingshun

doi:10.1016/j.matlet.2016.05.044

Cited by 23 publications

(17 citation statements)

References 8 publications

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“…Thus, the synthesis can be adjusted accordingly to achieve particles of defined 3D morphology and controlled chemical composition. Potential applications of these particles include as template molecules for large porous silica microspheres for protein separation, drug delivery systems, microcapsule systems for extrinsic self-healing applications, or, for instance, as templating materials used in energy storage applications [ 18 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Imaging of Single Anisotropic Polystyrene/Poly (Methacrylate) Microspheres with Complex Hierarchical Architecture

Wagner

Bredfeldt

et al. 2021

Polymers

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Monodisperse polystyrene spheres are functional materials with interesting properties, such as high cohesion strength, strong adsorptivity, and surface reactivity. They have shown a high application value in biomedicine, information engineering, chromatographic fillers, supercapacitor electrode materials, and other fields. To fully understand and tailor particle synthesis, the methods for characterization of their complex 3D morphological features need to be further explored. Here we present a chemical imaging study based on three-dimensional confocal Raman microscopy (3D-CRM), scanning electron microscopy (SEM), focused ion beam (FIB), diffuse reflectance infrared Fourier transform (DRIFT), and nuclear magnetic resonance (NMR) spectroscopy for individual porous swollen polystyrene/poly (glycidyl methacrylate-co-ethylene di-methacrylate) particles. Polystyrene particles were synthesized with different co-existing chemical entities, which could be identified and assigned to distinct regions of the same particle. The porosity was studied by a combination of SEM and FIB. Images of milled particles indicated a comparable porosity on the surface and in the bulk. The combination of standard analytical techniques such as DRIFT and NMR spectroscopies yielded new insights into the inner structure and chemical composition of these particles. This knowledge supports the further development of particle synthesis and the design of new strategies to prepare particles with complex hierarchical architectures.

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Section: Discussionmentioning

confidence: 99%

Chemical Imaging of Single Anisotropic Polystyrene/Poly (Methacrylate) Microspheres with Complex Hierarchical Architecture

Wagner

Bredfeldt

et al. 2021

Polymers

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“…Porous polymer particles have attracted considerable interest in various applications ranging from clinical diagnostics [1], immobilization support for biocatalysts [2], separation processes like chromatography [3][4][5][6], ion exchange phases [7] to applications as adsorption materials [8,9] or as hard-templates [10][11][12] for inorganic materials with defined structures. In particular, porous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (p(GMA-co-EDMA)) has been widely used, as the epoxy ring of GMA can be derivatized in various ways by ring opening reactions [2,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Pore Parameters in Monodisperse Porous Poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) Particles Based on Response Surface Methodology

et al. 2022

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Monodisperse porous poly(glycidyl methacrylate-co–ethylene glycol dimethacrylate) particles are widely applied in different fields, as their pore properties can be influenced and functionalization of the epoxy group is versatile. However, the adjustment of parameters which control morphology and pore properties such as pore volume, pore size and specific surface area is scarcely available. In this work, the effects of the process factors monomer:porogen ratio, GMA:EDMA ratio and composition of the porogen mixture on the response variables pore volume, pore size and specific surface area are investigated using a face centered central composite design. Non-linear effects of the process factors and second order interaction effects between them were identified. Despite the complex interplay of the process factors, targeted control of the pore properties was possible. For each response a response surface model was derived with high predictive power (all R2predicted > 0.85). All models were tested by four external validation experiments and their validity and predictive power was demonstrated.

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“…Monodispersed spherical polymer microspheres play an important role in many fields due to their uniform sizes and structures, such as in controlled release of stored materials [1,2,3], fabrication of cavities or interspaces templates from microspheres [4,5], and selective adsorption or separation of substances as microreactors [6,7]. Polyvinyl alcohol (PVA) is an inexpensive, commonly used, nontoxic, biocompatible polymer, which is rich in hydroxyl groups and can be easily modified.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Rapid Fabrication of Tunable Polyvinyl Alcohol Microspheres for Adsorption Applications

et al. 2019

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Monodisperse polyvinyl alcohol (PVA) microspheres have been widely used for targeted drug delivery, embolization, and templates. However, the fast and facile fabrication of PVA microspheres with uniform size and internal structure and good sphericity remains a challenge. In this study, the PVA microspheres with uniformity in the size, shape, and internal structure were rapidly fabricated, using single-emulsion droplet templates by an on-chip approach. First, we designed a polydimethylsiloxane (PDMS) microfluidic chip integrated with three functional units, used for the droplet generation, mixing of reagents, and pre-curing of PVA microspheres, respectively. Then, we precisely controlled the generation of PVA aqueous droplets, mixing of reagents, and the gelation rate for the production of high-quality microspheres by adjusting the pH value, flow rate, and the channel structure. The prepared PVA microspheres are characterized with good sphericity, uniform internal structure, and narrow size distribution. The microspheres have good adsorption capacity and recyclability for small-molecule drugs, as demonstrated by the adsorption and desorption of methylene blue (MB). The adsorption behavior is well described by the pseudo-second-order model, and intraparticle diffusion is as fast as the external film diffusion.

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Preparation of monodisperse large-porous silica microspheres with polymer microspheres as the templates for protein separation

Cited by 23 publications

References 8 publications

Chemical Imaging of Single Anisotropic Polystyrene/Poly (Methacrylate) Microspheres with Complex Hierarchical Architecture

Chemical Imaging of Single Anisotropic Polystyrene/Poly (Methacrylate) Microspheres with Complex Hierarchical Architecture

Rational Design of Pore Parameters in Monodisperse Porous Poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) Particles Based on Response Surface Methodology

Microfluidic Rapid Fabrication of Tunable Polyvinyl Alcohol Microspheres for Adsorption Applications

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