Preparation of monodisperse and size-controlled poly(ethylene glycol) hydrogel nanoparticles using liposome templates

An, Se Yong; Bui, Minh Phuong Ngoc; Nam, Yun Jung; Han, Kwi Nam; Li, Cheng Ai; Choo, Jaebum; Lee, Eun Kyu; Katoh, Shigeo; Kumada, Yoichi; Seong, Gi Hun

doi:10.1016/j.jcis.2008.11.022

Cited by 53 publications

(36 citation statements)

References 42 publications

(43 reference statements)

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“…Since their discovery, a large number of studies have been carried out to understand their biophysical and biochemical properties, and possible applications. They have been used as: model membrane systems to study the basic nature of cell membranes [6], in biochemistry and molecular biology [6,18], in analytical methods [18], in microfluidic technologies [19], as a template for the production of nanogels [20], in cosmetics and food technology [21,22], in imaging [23], as drug delivery systems in pharmacology [24][25][26], and in TE [27]. In this section, we will revisit the liposome properties, their formulation/functionalization, preparation methods and stability.…”

Section: Liposomesmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

319

217

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Liposomesmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

319

217

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“…Meanwhile, the cinnabar should avoid to be put together with the drugs containing Al element like alum, also can not be placed in aluminum carmine grinding device, or stored in the aluminum containers. Due to chemical reaction with the aluminum, Cinnabar occurs to produce aluminum gray amalgam, leading to poisoning [42][43][44][45].…”

Section: (4) Improper Methods Of Preparation and Takingmentioning

confidence: 99%

Advance and Prospect of Nanoscale Chinese Medicine

Wu¹

2010

Nano BioMed ENG

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Over the past few years, nanoscale Chinese medicine has emerged as a new exciting field in which theoretical and experimental studies of structure and function of nanoscale Chinese drugs have become a focus, and the importance of quality standardization of nanoscale medicament of Chinese traditional medicine as specific drugs to the fundamental development in traditional Chinese drugs has begun to be recognized. In particular, Chinese medicine dispersion, surface potentials, envelopment ratio, loading drug amounts, in vivo metabolism dynamics, bio-distribution, drug-releasing in vitro, etc., have become a new interdisciplinary frontier in life science and Chinese traditional medicine. There is an increasing need for a more systematic study of the basic issues involved in traditional Chinese medicine and a more active participation of researchers in the application area of nanoscale traditional Chinese drugs. Some advances have been and are being made in nanoscale Chinese herbs, mineral medicine including mongolia drugs such as cinnabar, with enormous prospect in clinical disease therapy. Here we review some of the main advances in this field over the past few years, explore the application prospects, and discuss the concepts, issues, approaches, and challenges, with the aim of stimulating a broader interest in developing nanoscale Chinese medicine.

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“…The current methods of controlling or reducing the particle size during preparation were usually to change the power of ultrasound, stirring speed, temperature, lipid ratio, etc. 15 The main difference between the work presented here and other optimized works was the adoption of dextran gel-assisted liposome formation method. Dextran gel (commerce name: Sephadex) was commonly used in size exclusion chromatography (SEC) which worked by trapping smaller molecules in the pores of a particle.…”

Section: Introductionmentioning

confidence: 91%

Effect of Dextran Gel on Preparation of Nano-liposomes Loaded with Ginkgolide

Yuan¹,

Chen²,

Jian³

et al. 2010

Bulletin of the Korean Chemical Society

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The objective of this paper was to investigate the effect of dextran gel on preparation of nano-liposomes loaded with ginkgolide. During preparation, Sephadex G75, G50 and G25 were added in the aqueous phase respectively. From the experiment, nano-liposomes prepared by dextran gels were found spherical and smooth. The result indicated that aperture of dextran gels were narrower, particle size of nano-liposomes was smaller (207.13 ~ 89.16 nm) and zeta potential was greater (-36.2 ~ -29.5 mV) in more negative. The study also revealed that differences of the entrapment efficiency and drug loading among the three types of nano-liposomes were not significant. In vitro drug release test demonstrated that nano-liposomes had a better controlled release. To conclude, by using dextran gel in the preparation of nano-liposome loaded with ginkgolide, the particle size could be effectively controlled and the drug stability could be improved.

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Preparation of monodisperse and size-controlled poly(ethylene glycol) hydrogel nanoparticles using liposome templates

Cited by 53 publications

References 42 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Advance and Prospect of Nanoscale Chinese Medicine

Effect of Dextran Gel on Preparation of Nano-liposomes Loaded with Ginkgolide

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