Preparation of molecularly imprinted adsorptive resin for trapping of ligustrazine from the traditional Chinese herb Ligusticum chuanxiong Hort.

Guo, Zhuang; Guo, Tingting; Guo, Mufan

doi:10.1016/j.aca.2008.02.039

Cited by 27 publications

(16 citation statements)

References 41 publications

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“…This is the application area that has found most commercial viability, as witnessed by the presence of several products on the market. The bulk of the MISPE studies reported to date…”

Section: Applicationsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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SummaryHerein we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004 to 2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004 which were omitted in the first instalment of this series covering the years 1930 to 2003. 1 In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed.2

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“…This is the application area that has found most commercial viability, as witnessed by the presence of several products on the market. The bulk of the MISPE studies reported to date…”

Section: Applicationsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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“…Endophytes are considered as a promising source for bioactive metabolites and only few plant species of the entire plant kingdom on earth have been examined so far [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Metabolites of Alternaria Alternata, an Endophyte of the Medicinal Plant Bidens Bipinnata

Abdou

Dawoud

2020

Int J Pharm Pharm Sci

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Objective: Endophytes are widely spread in the plant kingdom and represent a very promising source of biologically active natural products. The medicinal plant Bidens bipinnata Lin. (Asteraceae) which is known for its anti-inflammatory, antifungal and antitumor effects has been chosen for the investigation of its endophyte to search for bioactive metabolites. Methods: An endophytic Alternaria alternata species was isolated from the leaves of the plant B. bipinnata Lin. To investigate the metabolic profile of this endophytic fungus it was cultivated in several culture media as static and shaken culture. The antimicrobial and cytotoxic activities of the ethyl acetate extracts of the fungus were examined. Extracts exhibiting highest antimicrobial activities in agar diffusion assay and cytotoxicity against HeLa cancer cell line were subjected to activity-guided chromatographic fractionation for the identification of bioactive metabolites. A cytotoxic assay was performed on the isolated compounds against HeLa cancer cell lines as well as cytostatic activity tests against HUVEC and K-562 cell lines. Results: Chromatographic fractionation resulted in the isolation and identification of alternariol and tentoxin from the extract of the fungus cultivated in medium M5 while sterigmatocystin was isolated in addition to alternariol and tentoxin from the extract of the fungus grown in medium M25. Both alternariol and sterigmatocystin proved to be of moderate cytotoxicity and weak cytostatic activity with alternariol showing higher cytotoxic activity than sterigmatocystin. Highest cytotoxicity against HeLa cell lines was observed for tentoxin with a CC50 of 22.5 µg/ml. Conclusion: This study presents the isolation and identification of the bioactive metabolites alternariol, sterigmatocystin and tentoxin from the endophyte A. alternata in addition to the antifungal activity of the strain extract as well as the cytotoxic and cytostatic activities of the isolated metabolites against HeLa, HUVEC and K-562 cell lines, respectively.

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“…Tetramethylpyrazine (TMP) is an alkaloid found in the roots of Ligusticum chuanxiong . This compound is present in many natural herbs that are used to treat various diseases such as cardiovascular disease and infectious bursal disease .…”

Section: Introductionmentioning

confidence: 99%

Effect of tetramethylpyrazine (TMP) on Ca²⁺ signal transduction and cell viability in a model of renal tubular cells

Fang

Chou

Liang

et al. 2017

J Biochem & Molecular Tox

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Tetramethylpyrazine (TMP) is a compound purified from herb. Its effect on Ca2+ concentrations ([Ca2+]i) in renal cells is unclear. This study examined whether TMP altered Ca2+ signaling in Madin‐Darby canine kidney (MDCK) cells. TMP at 100–800 μM induced [Ca2+]i rises, which were reduced by Ca2+ removal. TMP induced Mn2+ influx implicating Ca2+ entry. TMP‐induced Ca2+ entry was inhibited by 30% by modulators of protein kinase C (PKC) and store‐operated Ca2+ channels. Treatment with the endoplasmic reticulum Ca2+ pump inhibitor 2,5‐di‐tert‐butylhydroquinone (BHQ) inhibited 93% of TMP‐evoked [Ca2+]i rises. Treatment with TMP abolished BHQ‐evoked [Ca2+]i rises. Inhibition of phospholipase C (PLC) abolished TMP‐induced responses. TMP at 200–1000 μM decreased viability, which was not reversed by pretreatment with the Ca2+ chelator 1,2‐bis(2‐aminophenoxy)ethane‐N,N,N′,N′‐tetraacetic acid‐acetoxymethyl ester. Together, in MDCK cells, TMP induced [Ca2+]i rises by evoking PLC‐dependent Ca2+ release from endoplasmic reticulum and Ca2+ entry via PKC‐sensitive store‐operated Ca2+ entry. TMP also caused Ca2+‐independent cell death.

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Preparation of molecularly imprinted adsorptive resin for trapping of ligustrazine from the traditional Chinese herb Ligusticum chuanxiong Hort.

Cited by 27 publications

References 41 publications

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Cytotoxic Metabolites of Alternaria Alternata, an Endophyte of the Medicinal Plant Bidens Bipinnata

Effect of tetramethylpyrazine (TMP) on Ca²⁺ signal transduction and cell viability in a model of renal tubular cells

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Preparation of molecularly imprinted adsorptive resin for trapping of ligustrazine from the traditional Chinese herb Ligusticum chuanxiong Hort.

Cited by 27 publications

References 41 publications

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Cytotoxic Metabolites of Alternaria Alternata, an Endophyte of the Medicinal Plant Bidens Bipinnata

Effect of tetramethylpyrazine (TMP) on Ca2+ signal transduction and cell viability in a model of renal tubular cells

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Effect of tetramethylpyrazine (TMP) on Ca²⁺ signal transduction and cell viability in a model of renal tubular cells