Preparation of micron-size monodisperse polymer microspheres having crosslinked structures and vinyl groups

Okubo, Masayoshi; Katayama, Yoshikazu; Yamamoto, Y.

doi:10.1007/bf00665494

Cited by 78 publications

(40 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from dispersions of homopolymers, those of several copolymers and cross-linked polymers have also been reported to be prepared by this process. 3,[13][14][15][16] In a typical dispersion polymerization, the monomer, the initiator, and the stabilizer are soluble but the polymer formed is insoluble in the dispersion medium, and, therefore, the latter separates out from the medium as it is formed. The separated polymer adsorbs the polymeric stabilizer, (or its product grafted with the forming polymer) on its surface in order to decrease the surface free energy and the resulting polymer particles become stable.…”

Section: Introductionmentioning

confidence: 99%

Dispersion polymerization of acrylamide: Part II. 2,2?-Azobisisobutyronitrile initiator

Ray

Mandal

1999

J. Polym. Sci. A Polym. Chem.

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Dispersion polymerization of acrylamide: Part II. 2,2?-Azobisisobutyronitrile initiator

Ray

Mandal

1999

J. Polym. Sci. A Polym. Chem.

View full text Add to dashboard Cite

“…[1][2][3] Moreover, for the production of particles with diameters above 5 m we suggested a novel swelling method to make polymer seed particles absorb a large amount of monomer prior to the seeded polymerization. 4 -7 We named it the "dynamic swelling method (DSM)."…”

Section: Introductionmentioning

confidence: 99%

Production of micron-sized monodispersed polymer particles by seeded polymerization for the dispersion of highly monomer-swollen particles prepared with submicron-sized polymer seed particles utilizing the dynamic swelling method

Okubo

Ise

Yamashita

1998

J. Polym. Sci. A Polym. Chem.

Self Cite

View full text Add to dashboard Cite

For the purpose of extending the size range of polymer seed particles used in “dynamic swelling method” (DSM), first it was verified theoretically that the submicron‐sized polymer particles produced by emulsion polymerization can also absorb a large amount of monomer by DSM in both equilibrium and kinetic control states. Next, on the basis of the theoretical results, experimentally about 2.6 μm‐sized styrene‐swollen polystyrene (PS) particles were prepared utilizing DSM in the presence of 0.64 μm‐sized monodispersed PS seed particles produced by emulsifier‐free emulsion polymerization. Moreover, 2.5 μm‐sized monodispersed PS particles were produced by the addition of cupric chloride as a water‐soluble inhibitor to depress the by‐production of submicron‐sized PS particles in the seeded polymerization at 30°C with 2,2′‐azobis(4‐methoxy‐2,4‐dimethylvaleronitrile) initiator. © 1998 John Wiley & Sons, Inc. J. Polym. Sci. A Polym. Chem. 36: 2513–2519, 1998

show abstract

“…[13] There are several ways of polymerizing polymer spheres. [14] Methods include seeded polymerization, [15] dispersion polymerization, [16] emulsion polymerization, [17] precipitation polymerization, [18] and suspension polymerization. [19] Out of all the above mentioned methods, only suspension polymerization is capable of producing particles with larger sizes that range from 5-1 000 mm while other techniques result in particles of a low micrometer or even nanometer range.…”

Section: Full Papermentioning

confidence: 99%

One Pot Synthesis of Surface PEGylated Core–Shell Microparticles by Suspension Polymerization with Surface Enrichment of Biotin/Avidin Conjugation

Ting¹,

Nguyen²,

Stenzel³

2009

Macromolecular Bioscience

View full text Add to dashboard Cite

Core-shell microparticles that consist of poly(vinyl neodecanoate) (VND) crosslinked with poly(ethylene glycol dimethacrylate) (EGDMA) as the core and poly(ethylene glycol methacrylate) (PEGMA) (Mn = 360 or Mn = 526 g . mol(-1)) as the shell have been synthesized using suspension polymerization by a conventional free radical polymerization process. Interfacial tension and stability tests show that PEGMA acts as an amphiphilic macromonomer and is located on the oil/water interface of the suspension system, thus forming an outer layer during the polymerization. Kinetic studies of the monomers' conversion of VND, EGDMA, and PEGMA have been carried out using (1)H NMR spectroscopy. EGDMA and PEGMA were found to have faster reaction rates compared to VND. Moreover, scanning electron microscopy showed that the polymerization of these particles starts from the shell and finishes towards the core. Consequently, the resulting microsphere is found to have a multi-layer structure. Biotin was covalently bound to the surface by the PEGMA hydroxy groups. Conjugation of biotin with streptavidin PE (phycoerythrin) was subsequently carried out. Confocal microscopy was used to confirm the presence of fluorescing streptavidin. The amount of avidin conjugated to the microspheres was calculated by the release of a 2-(4-hydroxyphenylazo)benzoic acid/avidin complex using UV/vis spectroscopy. One avidin molecule was found to occupy 7 nm(2) on the surface of the microspheres.

show abstract

Preparation of micron-size monodisperse polymer microspheres having crosslinked structures and vinyl groups

Cited by 78 publications

References 6 publications

Dispersion polymerization of acrylamide: Part II. 2,2?-Azobisisobutyronitrile initiator

Dispersion polymerization of acrylamide: Part II. 2,2?-Azobisisobutyronitrile initiator

Production of micron-sized monodispersed polymer particles by seeded polymerization for the dispersion of highly monomer-swollen particles prepared with submicron-sized polymer seed particles utilizing the dynamic swelling method

One Pot Synthesis of Surface PEGylated Core–Shell Microparticles by Suspension Polymerization with Surface Enrichment of Biotin/Avidin Conjugation

Contact Info

Product

Resources

About