Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation

Justen, Anna; Kurth, Christopher; Schaldach, Gerhard; Thommes, Markus

doi:10.1002/ceat.202200357

Cited by 4 publications

(8 citation statements)

References 57 publications

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“…It was chosen based on its UV traceability and high solubility in acetone for high particle mass load in the aerosol. Moreover, celecoxib has a high resistivity of about 4.5 × 10 13 Ωcm [23], which was considered to be particularly challenging in the ESP due to the back corona.…”

Section: Methodsmentioning

confidence: 99%

“…A custom-made spray dryer was used to generate particles [23]. An aqueous or acetone solution was nebulized with an ultrasonic atomizer operating at a high frequency of 3.2 MHz.…”

Section: Spray Dryingmentioning

confidence: 99%

“…Drug particles were deposited onto the hot xylitol and an increased drug dissolution was found [22]. Nevertheless, the process time was found to be limited by the built up particle layer on the xylitol melt due to back corona effects [23].…”

Section: Introductionmentioning

confidence: 99%

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Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations

Justen,

Weltersbach,

Schaldach

et al. 2024

Processes

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Electrostatic precipitators (ESP) are especially known for the efficient separation of micron and submicron particles from aerosols. Wet electrostatic precipitators are particularly suitable for highly resistive materials. Using these, particles can be directly transferred into a liquid for further processing or safer handling, which is advantageous for either hazardous or valuable materials. In this work, a wet ESP, which enables the separation of highly resistive particles into a heated liquid, was designed and investigated. To do this, spray-dried drug particles were embedded in a molten sugar alcohol to enhance the drug dissolution rate. After cooling, the solidified product showed advantageous properties such as a high drug dissolution rate and easy handling for further processing. For the design of the wet ESP, different discharge electrode configurations were tested. A wall film served as the collection electrode, which was generated by a specially designed distributer die. A laminar flow regime was achieved with a homogeneous film serving as the collection electrode, which is particularly important for a high separation efficiency. A prototype was designed and constructed in this respect. The particle separation into hot liquids or onto hot surfaces is challenging due to thermal effects in ESPs. The influence of thermophoresis and drag force on the particle transport was investigated, and optimum operation parameters were found for the present ESP. A broad field of applications can be covered with the presented device, where particles are embedded in even hot liquids to form liquid suspensions or, as it is presented here, solid dispersions. The dissolution of the drug-containing solid dispersion was studied in vitro. A remarkably faster drug dissolution was observed from the solid dispersion, as compared to a powder mixture of the drug and xylitol.

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Section: Methodsmentioning

confidence: 99%

“…A custom-made spray dryer was used to generate particles [23]. An aqueous or acetone solution was nebulized with an ultrasonic atomizer operating at a high frequency of 3.2 MHz.…”

Section: Spray Dryingmentioning

confidence: 99%

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Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations

Justen,

Weltersbach,

Schaldach

et al. 2024

Processes

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“…In the past, solid crystalline suspension showed a fast dissolution of poorly soluble drugs, as well as long-term stability and compatibility of crystalline sugar alcohols with several drugs [ 18 , 29 ]. Different manufacturing methods were presented, such as hot melt extrusion [ 30 , 31 , 32 ], co-milling [ 18 ], melt electrostatic precipitation [ 33 , 34 , 35 ] and melt milling [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations

Justen,

Schaldach,

Thommes

2024

Pharmaceutics

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Solid dispersions are a promising approach to enhance the dissolution of poorly water-soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high thermodynamic stability. To understand the mechanisms leading to the faster dissolution of solid crystalline formulations, physical mixtures of the poorly soluble drugs celecoxib, naproxen and phenytoin were investigated in the flow through cell (apparatus 4). The effect of drug load, hydrodynamics in the flow through cell and particle size reduction in co-milled physical mixtures were studied. A carrier- and drug-enabled dissolution could be distinguished. Below a certain drug load, the limit of drug load, carrier-enabled dissolution occurred, and above this value, the drug defined the dissolution rate. For a carrier-enabled behavior, the dissolution kinetics can be divided into a first fast phase, a second slow phase and a transition phase in between. This study contributes to the understanding of the dissolution mechanism in solid crystalline formulations and is thereby valuable for the process and formulation development.

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“…The spray deposition could be used for the fabrication of the CIS photo-absorbing layer instead of the high-cost vacuum-based process. For the combination scheme of electrostatic and ultrasonic atomization, the electric eld is generally introduced in the atomizing area [21], and corona charges [22][23] [24] are used to avoid introducing high-voltage electrostatic charges to the atomization surface and only play a role in beam ow, which has little effect on ultrasonic atomization. This paper presents an electrostatic-assisted ultrasonic spraying experimental device.…”

Section: Introductionmentioning

confidence: 99%

Investigation of electrostatic-assisted ultrasonic atomization and spraying

Yang,

Yuan,

Zhang

et al. 2024

Int J Adv Manuf Technol

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Ultrasonic atomization technology has been widely used in industry in recent years due to its higher atomization e ciency. This paper proposes a method of electrostatic-assisted ultrasonic atomization spraying and designs a special ultrasonic power supply that can directly introduce high-voltage static electricity onto the surface of the ultrasonic atomization so that the liquid can contact the charge and enhance the charging effect. This paper conducts numerical simulation analysis on the atomization process and statistically analyzes the numerical simulation atomization particle size through image processing. In addition, this paper designs experiments from two aspects of atomization particle size and lm-forming effect. The results show that the experimental results are consistent with the numerical simulation results, verifying the accuracy of the numerical simulation results. It shows that in the process of sub-droplet formation, the introduction of static electricity will increase the number of capillary waves, promote two mechanisms of the capillary pinch-off mechanism and the Rayleigh-Plain instability, reduce atomization particle size, and increase atomization e ciency. Compared with the traditional air ow beam method, the lm-forming surface quality of the electric eld beam method is higher and the surface roughness is lower. It solves the problem that air ow affects lm-forming quality in traditional ultrasonic spraying with the air ow beam method. It provides a theoretical basis and scienti c guidance for the application of electrostatic-assisted ultrasonic atomization technology in the atomization and lm preparation industry.

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Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation

Cited by 4 publications

References 57 publications

Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations

Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations

Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations

Investigation of electrostatic-assisted ultrasonic atomization and spraying

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