Preparation of MgFe2O4 microsphere using spray dryer for embolization therapy application

Abstract

MgFe 2 O 4 microspheres having a 2032 µm diameter range were prepared by a spray dryer using bead-milled nano-sized particles. A commercial powder having a several µm particle size was bead-milled to an approximate 6.2 nm crystallite size. The microspheres were obtained using the spray dryer when the air pressure was low (0.03 MPa). The yield of the MgFe 2 O 4 2032 µm microspheres was improved by combination of a low air pressure and high ferrite concentration in the slurry. The heat generation ability in an AC magnetic field (370 kHz, 1.77 kA/m) was improved by the bead milling.

Investigations of superparamagnetism in magnesium ferrite nano-sphere synthesized by ultrasonic spray pyrolysis technique for hyperthermia application

“…It has excellent chemical stability with inverse spinel structured, which have found a number of modern technological applications in microwave devices, catalysis, adsorption, gas and humidity sensor, ferrofluid technology, fuel cells, magnetic core of coils and also used in an inorganic pigment [11][12][13]. Aono et al [14] found that MgFe 2 O 4 has the highest heating ability compare to other commercial ferrite powders of MFe 2 O 4 (M = Mg, Mn, Fe, Co, Ni, Cu and Sr) in alternating magnetic field which is one of the interesting applications in hyperthermia therapy. In addition, these MgFe 2 O 4 nanoparticles would be suitable for the use in the human body, because the elements present in these material are nontoxic [15].…”

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

“…51),52) Bead-milled MgFe 2 O 4 and Y 3 Fe 5 O 12 were tested for the preparation of microspheres using the spray-drying method. 53),54) Figure 11 shows a spray-drier used for the preparation of the microspheres. The slurry for the spray-drier was obtained as a mixture of the bead-milled Y 3 Fe 5 O 12 and purified water, and then sprayed by heated air at 200°C as small droplets by the spraydrier with an nozzle atomizer.…”

High heat generation ability in AC magnetic field of nano-sized superparamagnetic Y _3 Fe _5 O _12 ferrite powder prepared by physical bead milling

“…The microspheres with a 20-30 μm diameter range could be obtained by spray drying using a water-based slurry of ferrite MgFe 2 O 4 nanopowders [21].…”