Preparation of metal nanoband microelectrode on poly(dimethylsiloxane) for chip-based amperometric detection

Chen, Shao-Peng; Wu, Jian; Yu, Xiao-Dong; Xu, Jing‐Juan; Chen, Hong‐Yuan

doi:10.1016/j.aca.2010.03.043

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…We studied the effect of the gap size from 20 to 60 mm on the signal of glucose. The results were in agreement with the previous work [44] that the serious background current and noise level would occur if the gap was less than 40 mm, whereas both of the background current and noise level could be minimized and were approximately at the same level when the distance between 40 and 60 mm. Therefore, the optimal gap size was set to be 40 mm.…”

Section: Integration Of the Electrophoretic Separation And Electrochesupporting

confidence: 94%

“…1A). By comparison with its responses with Ag/AgCl reference electrode [44], there was a positive shift of 250 mV on potential when the gold nanoband was applied as reference electrode. In 5 Â 10 À3 M ferricyanide/ ferrocyanide solution, we could also get the same trend (inset, Fig.…”

Section: Characterization Of the Nanoband Electrodesmentioning

confidence: 99%

“…The protocol for the fabrication of the PDMS microchip was similar as reported previous with the soft lithography technology [44,45]. Briefly, a double-layer toner with the thickness of $15 mm on the transparency film printed by laser printer was used as the relief.…”

Section: Fabrication Of Multichannel Microchips and Their Integrationmentioning

confidence: 99%

“…The fabrication method of metal films (gold or copper) on PDMS slices was performed according to the previous protocol [44]. We could obtain metal layers via regionselective electroless deposition of gold or copper films on the same PDMS substrate through selective region oxidation by air plasma.…”

Section: Fabrication Of Nanoband Electrode Arraymentioning

confidence: 99%

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Multi‐parameter detection of diabetes mellitus on multichannel poly(dimethylsiloxane) analytical chips coupled with nanoband microelectrode arrays

Chen

et al. 2010

Electrophoresis

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This article demonstrates a novel method for multi-parameter detection of diabetes mellitus. We propose an approach for fabrication of a 3-D metal films array with gold and copper using electroless deposition technique on PDMS substrate. The obtained PDMS slices containing metal films are superimposed layer by layer as a sandwich structure to form 3-D metal films array. The cross-sections of the array could be used as nanoband array electrochemical detectors, which are further integrated with a multichannel microchip for simultaneously detecting multi-parameter of diabetes mellitus, including glucose and metabonomics of diabetes containing aldehyde compounds (glyoxal and methylglyoxal) and short organic acids (lactate, urate and 2-hydroxybutyrate). Under optimized separation and detection conditions, glucose, aldehyde compounds and short organic acids respond linearly in the concentration range of 10-2000, 1-500 and 5-600 μM, with the LODs of 4, 0.5 and 3 μM for glucose, aldehyde compounds and short organic acids, respectively. This system is successfully employed to detect these compounds in serums. This study reveals that the electrochemical array detectors with different materials integrated with multichannel microchip provide a flexible and inexpensive approach for routine, simultaneous and direct detection of some metabolites in metabonomics.

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Section: Integration Of the Electrophoretic Separation And Electrochesupporting

confidence: 94%

Section: Characterization Of the Nanoband Electrodesmentioning

confidence: 99%

Section: Fabrication Of Multichannel Microchips and Their Integrationmentioning

confidence: 99%

Section: Fabrication Of Nanoband Electrode Arraymentioning

confidence: 99%

See 2 more Smart Citations

Multi‐parameter detection of diabetes mellitus on multichannel poly(dimethylsiloxane) analytical chips coupled with nanoband microelectrode arrays

Chen

et al. 2010

Electrophoresis

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“…However, the alignment between the off-chip WE and the CE channel end is a bottleneck which determines the sensitivity and reproducibility of detection. Presently, micro-disk electrodes [29][30][31] or planar-type electrodes [32][33] are used for the off-chip detection, as listed in Table 3. If the gap between the WE and channel end is well controlled, end-channel detection can obtain a low LOD.…”

Section: End-channel Detectionmentioning

confidence: 99%

Development of a Capillary Electrophoresis Chip with Integrated Electrochemical Sensors

Ching-Chou¹

2016

AUSMT

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Capillary electrophoresis (CE) chips with amperometric integration offers improved portability, high detection throughput, small sample and reagent volumes, low driving voltages and sample injection and separation. This article reviews recent CE chip developments and applications in the integration of amperometric sensors. We describe the development of three different configurations (in-channel, off-channel and end-channel). CE chips with integrated EC detectors have great promise in applications including diagnostics, environmental monitoring and biological assays.

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Recent advances in microchip electrophoresis for amino acid analysis

Feng

et al. 2013

Anal Bioanal Chem

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With the maturation of microfluidic technologies, microchip electrophoresis has been widely employed for amino acid analysis owing to its advantages of low sample consumption, reduced analysis time, high throughput, and potential for integration and automation. In this article, we review the recent progress in amino acid analysis using microchip electrophoresis during the period from 2007 to 2012. Innovations in microchip materials, surface modification, sample introduction, microchip electrophoresis, and detection methods are documented, as well as nascent applications of amino acid analysis in single-cell analysis, microdialysis sampling, food analysis, and extraterrestrial exploration. Without doubt, more applications of microchip electrophoresis in amino acid analysis may be expected soon.

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Preparation of metal nanoband microelectrode on poly(dimethylsiloxane) for chip-based amperometric detection

Cited by 8 publications

References 42 publications

Multi‐parameter detection of diabetes mellitus on multichannel poly(dimethylsiloxane) analytical chips coupled with nanoband microelectrode arrays

Multi‐parameter detection of diabetes mellitus on multichannel poly(dimethylsiloxane) analytical chips coupled with nanoband microelectrode arrays

Development of a Capillary Electrophoresis Chip with Integrated Electrochemical Sensors

Recent advances in microchip electrophoresis for amino acid analysis

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