Preparation of mesostructured silica–micelle hybrids and their conversion to mesoporous silica modified controllably with immobilized hydrophobic blocks by using triethoxysilyl-terminated PEO–PPO–PEO triblock copolymer

Abstract

Mesostructured silica having mesopore surface functionalized with poly(ethylene oxide) 20 -bpoly(propylene oxide) 70 -b-poly(ethylene oxide) 20 (EO 20 PO 70 EO 20 , P123) micelles was synthesized by using triethoxysilyl-terminated P123 (TES-P123) with dual functions of templating and surface anchoring. The amount of anchored P123 was controlled by mixing TES-P123 and conventional P123 as a cotemplate and the subsequent removal of the cotemplate by extraction. All the samples show the presence of ordered mesopores after the extraction. Unexpectedly, the d-spacing and the pore size increased after the extraction when the ratio of TES-P123/(TES-P123 + P123) was over 75%, which is explained by an osmotic force caused by anchored P123 swollen with THF during the extraction. To evaluate the stability of anchored P123, ibuprofen was simultaneously incorporated into mesopores during the formation of mesostructured silica. When TES-P123 was exclusively used, the percentage of retained P123 after the extraction of IBU was higher than that found for the case of conventional P123. This approach will open a new way to stabilize assembled amphiphiles in regularly ordered siloxane frameworks.

Hierarchical mesoporous silicas templated by PE-b-PEO-b-PLA triblock copolymer for fluorescent drug delivery

“…[16][17][18][19][20][21][22][23][24][25] They are also used for the preparation of mesoporous organic materials and mesoporous carbon materials. [26][27][28][29][30][31] The triblock copolymers are also used to prepare hierarchically mesoporous materials with lamellae, and core/shell cylinders structure. 32,33 In our previous studies, ABA/BC-type block copolymer of Pluronic F127/poly(ethylene oxide-b-caprolactone) (PEO-b-PCL) as co-templates and ABC-type triblock copolymers of poly(ethylene-b-ethylene oxide-b-caprolactone) (PE-b-PEO-b-PCL) as single templates are used to prepare hierarchical mesoporous silica material through EISA.…”

“…For example, mesoporous silica materials with the same pore size but with different mesoporous morphology (e.g., hexagonal cylinder vs. face-centered cubic) have different drugs-loading and drugs-releasing property. [37][38][39][40][41][42][43][44] The drug loading capacity of a mesoporous silica depends on the surface area of the material while the release rate is regulated by the morphology of porous structure. 43 The most of the drugs release to surface on the both side of the hole through meso-size channel and the small part of the drugs release through the micro-size pores of inorganic wall from 2Dhexagonal cylindrical mesopore (channel-typed mesopores).…”

Mesoporous silicas templated by symmetrical multiblock copolymers through evaporation-induced self-assembly

“…[31][32][33][34][35][36][37][38][39][40][41] The EISA strategy can also be used broadly for the preparation of mesoporous organic materials, mesoporous polymer resins, 31,[42][43][44][45][46][47][48][49] and mesoporous carbons. 32,[50][51][52][53][54][55][56] In other words, EISA provides an approach toward the formation of ordered mesoporous nanostructures [57][58][59] when combined with unusual AB diblock copolymers 31,32,37 or ABC triblock terpolymers 35 as templates. Many studies of mesoporous materials have been performed because of their potential applications in catalysis, 60 adsorption, 61 and drug delivery.…”

Solvent-tuning of ordered mesoporous silicas prepared through evaporation-induced self-assembly templated by poly(ethylene oxide-b-ε-caprolactone)

“…Several synthetic strategies have been developed based on poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers as templates, allowing the preparation of many highly ordered large-pore mesoporous materials. 3,4,17,21,23,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] The EISA strategy involves templating of the mesophase growth during evaporation of a volatile solvent. As a result, it is important to have control over the rate of solvent evaporation; for example, when preparing long-range-ordered mesoporous materials through a spray drying method.…”