Preparation of melatonin novel-mucoadhesive nanoemulsion used in the treatment of depression

Ahmad, Niyaz; Khalid, Mohammed Saifuddin; Ramadhan, Ayman Makki Al; Alaradi, Mohammed Zaki; Hammad, Mohammed Riyad Al; Ansari, Khalid; Alqurashi, Yousef D.; Khan, Mohd Faiyaz; Albassam, Ahmed A.; Ansari, Mohammad Javed; Akhtar, Sultan; Dilshad, Mubah

doi:10.1007/s00289-022-04436-3

Cited by 6 publications

(5 citation statements)

References 51 publications

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“…route, which was also reported before ( Table 9 ). 19 Finally, we concluded that the i.n. route is the main route to target the brain directly.…”

Section: Resultsmentioning

confidence: 80%

“…Opt-SC CS NPs enhanced the bioavailability of SC in the brain due to the stronger transcellular transport of SC by the olfactory-neurons into the brain via the endocytic pathway. 19 …”

Section: Resultsmentioning

confidence: 99%

“…Opt-SC CS NPs enhanced the bioavailability of SC in the brain due to the stronger transcellular transport of SC by the olfactory-neurons into the brain via the endocytic pathway. 19 The C max (983.64 ± 65.82 ng g −1 ) and AUC (12405.15 ± 91.53 ng min g −1 ) increased signicantly via the i.n. administration of SC CS NPs compared to S-allyl cysteine S (i.n.)…”

Section: Pd-study Of Cerebral Ischemia Of Optimized-sc Cs Npsmentioning

confidence: 94%

“…These advantages include bypassing the hepatic rst-pass metabolism, overcoming the blood-brain barrier, and providing a convenient, non-invasive route for drug administration. 2,18,19 However, it is crucial to consider that drugs delivered intranasally tend to have a short residence time in the nasal passage. Therefore, a key parameter in developing novel nanoformulations for intranasal use is to enhance their mucoadhesion and viscosity, which extends the residence time of drugs in the nasal passage.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment

Khan,

Ahmad,

Alkholifi

et al. 2024

RSC Adv.

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“…route, which was also reported before ( Table 9 ). 19 Finally, we concluded that the i.n. route is the main route to target the brain directly.…”

Section: Resultsmentioning

confidence: 80%

“…Opt-SC CS NPs enhanced the bioavailability of SC in the brain due to the stronger transcellular transport of SC by the olfactory-neurons into the brain via the endocytic pathway. 19 …”

Section: Resultsmentioning

confidence: 99%

Section: Pd-study Of Cerebral Ischemia Of Optimized-sc Cs Npsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment

Khan,

Ahmad,

Alkholifi

et al. 2024

RSC Adv.

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show abstract

“…Pharmacodynamic behavioral analysis of both the NE and suspension, performed using locomotor activity tests and the FST (forced swimming, climbing, and immobility), showed a markedly improved performance of the depressive rats treated with CS-MLT-NE. This indicates its potential as a treatment for depression [332].…”

Section: Melatoninmentioning

confidence: 85%

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Ashfaq,

Rasul,

Asghar

et al. 2023

IJMS

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Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one of the extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability of encapsulated compounds but also provide efficient targeting and reduce the risk of toxicity. Over the last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, and herbs have received more attention due to their remarkable biological and pharmacological health and medical benefits. However, their poor aqueous solubility, compromised stability, insufficient absorption, and accelerated elimination impede research in the nutraceutical sector. Owing to the possibilities offered by various LNPs, their ability to accommodate both hydrophilic and hydrophobic molecules and the availability of various preparation methods suitable for sensitive molecules, loading natural fragile molecules into LNPs offers a promising solution. The primary objective of this work is to explore the synergy between nature and nanotechnology, encompassing a wide range of research aimed at encapsulating natural therapeutic molecules within LNPs.

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Development and evaluation of polysorbate-80 coated Mangiferin PLGA nanoparticles used in the treatment of cerebral ischemia

Ahmad,

Khan,

Ullah

et al. 2023

Polym. Bull.

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Preparation of melatonin novel-mucoadhesive nanoemulsion used in the treatment of depression

Cited by 6 publications

References 51 publications

Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment

Preparation of novel S-allyl cysteine chitosan based nanoparticles for use in ischemic brain treatment

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Development and evaluation of polysorbate-80 coated Mangiferin PLGA nanoparticles used in the treatment of cerebral ischemia

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