Preparation of Magadiite-Sodium Alginate Drug Carrier Composite by Pickering-Emulsion-Templated-Encapsulation Method and Its Properties of Sustained Release Mechanism by Baker–Lonsdale and Korsmeyer–Peppas Model

Ge, Mingqiao; Li, Xinxiang; Li, Yueying; Alam, Safaet; Gui, Yuee; Huang, Yongchao; Cao, Luoxiang; Liang, Guodong; Hu, Guoqing

doi:10.1007/s10924-022-02426-0

Cited by 9 publications

(13 citation statements)

References 46 publications

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“…Several relevant recent studies (ref. [36][37][38][39][40][41][42][43][44][45][46][47] reporting typical values of a are as follows.…”

Section: Related Experimental Resultsmentioning

confidence: 99%

“…Ge et al 38 studied magadiite-sodium alginate drug carrier composites of different shapes and sizes. a is reported to be in the range from 0.40 to 0.66.…”

Section: Related Experimental Resultsmentioning

confidence: 99%

“…In agreement with the previous studies reviewed by Mircioiu et al, 7 recent studies (ref. [36][37][38][39][40][41][42][43][44][45][46][47] focused on various cargos and carriers show that a is often in the range from 0.45 to 0.85. As I have illustrated in Section III, the Weibull and Korsemeyer-Peppas expressions with this range of a can easily be reproduced by using the model under consideration with appreciable heterogeneity.…”

Section: Related Experimental Resultsmentioning

confidence: 99%

“…1. For qualitative illustration, I have further simplified (37) down to (38). The latter equation is e.g.…”

Section: In Combinationmentioning

confidence: 99%

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Release of molecules from nanocarriers

Zhdanov

2023

Phys. Chem. Chem. Phys.

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“…Several relevant recent studies (ref. [36][37][38][39][40][41][42][43][44][45][46][47] reporting typical values of a are as follows.…”

Section: Related Experimental Resultsmentioning

confidence: 99%

“…Ge et al 38 studied magadiite-sodium alginate drug carrier composites of different shapes and sizes. a is reported to be in the range from 0.40 to 0.66.…”

Section: Related Experimental Resultsmentioning

confidence: 99%

Section: Related Experimental Resultsmentioning

confidence: 99%

“…1. For qualitative illustration, I have further simplified (37) down to (38). The latter equation is e.g.…”

Section: In Combinationmentioning

confidence: 99%

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Release of molecules from nanocarriers

Zhdanov

2023

Phys. Chem. Chem. Phys.

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“…Baker–Lonsdale’s model has been most commonly applied to describe drug release from microcapsules and microspheres [ 58 ], but it also accounts for slow sustained release from spherical matrices [ 75 ]—which is the case depicted in Figure 4 a for PTX-LMNP. Hydrophobic PTX molecules tend to be slowly released from the lipidic PC layer coating PTX-LMNP, to which they are attracted through hydrophobic interactions.…”

Section: Discussionmentioning

confidence: 99%

Paclitaxel-Loaded Lipid-Coated Magnetic Nanoparticles for Dual Chemo-Magnetic Hyperthermia Therapy of Melanoma

et al. 2023

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Melanoma is the most aggressive and metastasis-prone form of skin cancer. Conventional therapies include chemotherapeutic agents, either as small molecules or carried by FDA-approved nanostructures. However, systemic toxicity and side effects still remain as major drawbacks. With the advancement of nanomedicine, new delivery strategies emerge at a regular pace, aiming to overcome these challenges. Stimulus-responsive drug delivery systems might considerably reduce systemic toxicity and side-effects by limiting drug release to the affected area. Herein, we report the development of paclitaxel-loaded lipid-coated manganese ferrite magnetic nanoparticles (PTX-LMNP) as magnetosomes synthetic analogs, envisaging the combined chemo-magnetic hyperthermia treatment of melanoma. PTX-LMNP physicochemical properties were verified, including their shape, size, crystallinity, FTIR spectrum, magnetization profile, and temperature profile under magnetic hyperthermia (MHT). Their diffusion in porcine ear skin (a model for human skin) was investigated after intradermal administration via fluorescence microscopy. Cumulative PTX release kinetics under different temperatures, either preceded or not by MHT, were assessed. Intrinsic cytotoxicity against B16F10 cells was determined via neutral red uptake assay after 48 h of incubation (long-term assay), as well as B16F10 cells viability after 1 h of incubation (short-term assay), followed by MHT. PTX-LMNP-mediated MHT triggers PTX release, allowing its thermal-modulated local delivery to diseased sites, within short timeframes. Moreover, half-maximal PTX inhibitory concentration (IC50) could be significantly reduced relatively to free PTX (142,500×) and Taxol® (340×). Therefore, the dual chemo-MHT therapy mediated by intratumorally injected PTX-LMNP stands out as a promising alternative to efficiently deliver PTX to melanoma cells, consequently reducing systemic side effects commonly associated with conventional chemotherapies.

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Formulation of hesperidin‐loaded in situ gel for ocular drug delivery: a comprehensive study

Gözcü,

Polat,

Gültekin

et al. 2024

J Sci Food Agric

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BackgroundAllergic conjunctivitis is one of the most common eye disorders. Different drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus sinensis L. (Rutaceae) fruit peels, with known anti‐inflammatory activity but low solubility, it was complexed with cyclodextrin and encapsulated in‐situ gel to extend the eye duration.ResultsThe optimized formulation comprised 1% hesperidin, 1.5% hydroxyethyl cellulose, and 16% poloxamer 407. The viscosity at 25°C was 492±82, at 35°C was 8875±248, pH was 7.01±0.03, gelation temperature was 34±1.3°C, and gelation time was 33±1.2 seconds. In vitro release exhibited 66% release within the initial two hours with a burst effect. With LOX inhibition test, it was determined that hesperidin showed activity at high doses on leukotyrens seen in the body in allergic diseases. In cell culture studies, the hesperidin cyclodextrin complex loaded in‐situ gel (Poloxamer 16%, HEC 1.5%) (BRN9‐CD) enhanced cell viability compared to the hesperidin solution. It was determined that BRN9‐CD did not cause any irritation in the ocular tissues in the Draize test.ConclusionThe findings of this study demonstrate the promising potential of the in‐situ gel formulation of hesperidin in terms of ease of application and residence time on the ocular surface. Due to its notable LOX inhibition activity and positive outcomes in the in vivo Draize test, it holds promise for incorporation into pharmaceutical formulations.This article is protected by copyright. All rights reserved.

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Preparation of Magadiite-Sodium Alginate Drug Carrier Composite by Pickering-Emulsion-Templated-Encapsulation Method and Its Properties of Sustained Release Mechanism by Baker–Lonsdale and Korsmeyer–Peppas Model

Cited by 9 publications

References 46 publications

Release of molecules from nanocarriers

Release of molecules from nanocarriers

Paclitaxel-Loaded Lipid-Coated Magnetic Nanoparticles for Dual Chemo-Magnetic Hyperthermia Therapy of Melanoma

Formulation of hesperidin‐loaded in situ gel for ocular drug delivery: a comprehensive study

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