Preparation of Long-Acting Superoxide Dismutase Using High Molecular Weight Polyethylene Glycol (41,000-72,000 Daltons)

Somack, Ralph; Saifer, Mark G.P.; Williams, L. David

doi:10.3109/10715769109145830

Cited by 36 publications

(17 citation statements)

References 9 publications

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“…Covalent conjugation of SOD with polyethylene glycol (PEG) increases cellular enzyme activities and the circulatory half-lives of these enzymes from less than 10 minutes to 40 hours, thus providing prolonged protection from partially reduced oxygen species (28).…”

Section: Resultsmentioning

confidence: 99%

Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase

Brodie²,

Tinling

2008

Otology &Amp; Neurotology

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Section: Resultsmentioning

confidence: 99%

Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase

Brodie²,

Tinling

2008

Otology &Amp; Neurotology

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“…The increase of SOD half life from approximately 25 minutes to several days was possible due to high MW PEG used for preparation. This procedure decreased immunogenity while retaining the enzymatic activity [34,35].…”

Section: Discussionmentioning

confidence: 99%

Topical superoxide dismutase reduces post‐irradiation breast cancer fibrosis

Campana

Zervoudis

Perdereau

et al. 2004

J Cellular Molecular Medi

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Fibrosis following breast radiotherapy for mammary cancer is a frequent undesired effect with objective (esthetic) and subjective (pain) consequences. Forty‐four patients with clinical radiofibrosis following conservative treatment of breast cancer were evaluated for the local antifibrosis effect of copper zinc superoxide dismutase [SOD(Cu/Zn)]. Extracted SOD(Cu/Zn) in a concentration of 3,600 units/mg was applied as ointment to the fibrotic affected area, b.i.d. for 90 days, in a total dose of 40 mg. The radiofibrosis intensity was scored on the basis of clinical criteria (pain and the fibrosis area) before and after SOD(Cu/Zn) treatment. SOD(Cu/Zn) was found to be effective in reducing radiation induced fibrosis by a lowering pain score in 36/39 patients and a decrease of the fibrotic area size in half cases, after 6 months. The intensity and changes of breast fibrosis were assessed also by mammography and, for the topographical distribution of subcutaneous temperature, by infrared thermography. Mammography density suggested decreased fibrosis in one third of patients. Thermography showed that fibrosis was accompanied by two zones clinically indistinctive: a central area with maximum thermal activity, called “Maximal Thermic zone” (MTZ) and a peripheral area with less thermal activity but higher than in the surrounding normal tissue, “Transitional Thermic Zone” (TTZ). Both MTZ and TTZ were significantly decreased in 36/44 patients after SOD(Cu/Zn) treatment. Clinical changes persisted all along the study. Treatment was well tolerated except for one case of local allergic reaction, and no important side effects. Molecular mechanisms involved are discussed. Further studies are running to confirm and explain these results.

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“…Modifications made to the structure of the enzyme, as well as its delivery vehicle have improved its applicability as a therapy by increasing the duration of action and increasing the availability of the enzyme. [48][49][50] The clinical success achieved with this potent antioxidant has stimulated interest in exploring natural occurring and more affordable antioxidant substances.…”

Section: Antioxidants Studied In Radiodermatitismentioning

confidence: 99%

The Use of Antioxidants in Radiotherapy-Induced Skin Toxicity

2013

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Radiation-induced skin damage is one of the most common complications of radiotherapy. In order to combat these side effects, patients often turn to alternative therapies, which often include antioxidants. Antioxidants such as those in the polyphenol chemical class, xanthine derivatives, tocepherol, sucralfate, and ascorbate have been studied for their use in either preventing or treating radiotherapy-induced skin damage. Apart from their known role as free radical scavengers, some of these antioxidants appear to alter cytokine release affecting cutaneous and systemic changes. We review the role of antioxidants in treating and preventing radiation-induced skin damage as well as the possible complications of using such therapy.

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Preparation of Long-Acting Superoxide Dismutase Using High Molecular Weight Polyethylene Glycol (41,000-72,000 Daltons)

Cited by 36 publications

References 9 publications

Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase

Long-Term Hearing Loss in Gerbils With Bacterial Meningitis Treated With Superoxide Dismutase

Topical superoxide dismutase reduces post‐irradiation breast cancer fibrosis

The Use of Antioxidants in Radiotherapy-Induced Skin Toxicity

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