Preparation of liposomes entrapping essential oil from Atractylodes macrocephala Koidz by modified RESS technique

Wen, Zhen; Liu, Bo; Zheng, Zongkun; You, Xuefu; Pu, Yitao; Li, Qiong

doi:10.1016/j.cherd.2010.01.020

Cited by 94 publications

(29 citation statements)

References 12 publications

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“…All of the vesicles were highly negatively charged, which is predictive of good stability on storage. Additionally, the incorporation of the payloads did not modify the surface charge of liposomes as compared to empty liposomes, thus confirming the localisation of the active compounds within the bilayer, as previously reported [24]. The amount of pompia essential oil and citral incorporated in the vesicles was very high (entrapment efficiency was around 86%), thus confirming the results of other authors [24].…”

Section: (Nm) Pi Zp (Mv) Ee (%)supporting

confidence: 89%

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

et al. 2020

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Citrus species extracts are well known sources of bio-functional compounds with health-promoting effects. In particular, essential oils are known for their antibacterial activity due to the high content of terpenes. In this work, the steam-distilled essential oil from the leaves of Citrus limon var. pompia was loaded in phospholipid vesicles. The physico-chemical characteristics of the essential oil loaded vesicles were compared with those of vesicles that were loaded with citral, which is one of the most abundant terpenes of Citrus essential oils. The biocompatibility of the vesicles was assessed in vitro in human keratinocytes. Furthermore, the antimicrobial activity of the vesicles was tested while using different bacterial strains and a yeast: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, respectively. The vesicles were small in size (~140 nm), slightly polydispersed (PI~0.31), highly negatively charged (~−73 mV), and able to incorporate high amounts of essential oil or citral (E%~86%). Pompia essential oil and citral exhibited antimicrobial activity against all of the assayed microorganisms, with P. aeruginosa being the least sensitive. Citral was slightly more effective than pompia essential oil against E. coli, S. aureus, and C. albicans. The incorporation of citral in vesicles improved its antifungal activity against C. albicans.

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Section: (Nm) Pi Zp (Mv) Ee (%)supporting

confidence: 89%

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

et al. 2020

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“…Nevertheless, a tendency toward instability could be seen regardless the composition and liposome structuration. Wen et al studied the factors that influenced the association efficiency and drug loading of Atractylodes macrocephala essential oil into liposomes prepared by rapid expansion of supercritical solutions (Wen et al, 2010). The key factors found were pressure, temperature and amount of co-solvent (ethanol).…”

Section: Essential Oilsmentioning

confidence: 99%

On the use of nanotechnology-based strategies for association of complex matrices from plant extracts

Zorzi

Carvalho

Poser

et al. 2015

Revista Brasileira de Farmacognosia

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Please cite this article in press as: Zorzi, G., et al. On the use of nanotechnology-based strategies for association of complexes matrices from plant extracts. Revista Brasileira de Farmacognosia (2015), http://dx.BJP 159 1-11 Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c tDepending on the method of extraction, plant extracts can contain an enormous variety of active molecules, such as phenolic compounds, essential oils, alkaloids, among others. In many cases, from a pharmacological point of view, it is interesting to work with crude extract or fractions instead of a single isolated compound. This could be due to multi-targeting effect of the extract, lack of knowledge of the active compounds, synergistic effect of the extract compounds, among others. In any case, in order to achieve a final product some issues must be overcome, including poor stability, solvent toxicity, and low solubility of the bioactive compound. Recently many nanotechnology-based strategies have been proposed as an alternative to solve these problems, especially liposomes, nanoemulsions and nanoparticles. In this sense, the present work aims to review the main nanotechnological approaches used for association of different plant extracts and the main achievements form using these technologies.

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“…Subsequently, the dense gas solution is depressurized and mixed with a phosphate buffer solution via a coaxial nozzle to form a liposome suspension. The suspension is finally freeze-dried [91].…”

Section: Rapid Expansion Of Supercritical Solutions (Ress)mentioning

confidence: 99%

Formation of Nanocarrier Systems by Dense Gas Processing

2014

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Nanocarrier systems, such as liposomes, polymersomes, and micelles, find applications in the delivery of a wide range of compounds, including targeted delivery of pharmaceuticals. Nanocarrier systems have the ability to increase the bioavailability, reduce toxicity, and avoid undesirable interactions of active pharmaceutical ingredients. In this work, a novel dense gas technique known as depressurization of an expanded solution into aqueous media (DESAM) was used to produce different types of nanocarrier systems. The effects of using different types of dense gases and different operating temperatures were investigated. Encapsulation of hydrophilic compounds in the vesicles (liposomes and polymersomes) was also studied. The highest encapsulation efficiencies in liposomes and polymersomes achieved were 10.2 and 9.7%, respectively. The DESAM process was also able to reduce the residual solvent content in the product to 2.2% (v/v), which is significantly lower than the solvent residual levels reported for conventional processing.

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Preparation of liposomes entrapping essential oil from Atractylodes macrocephala Koidz by modified RESS technique

Cited by 94 publications

References 12 publications

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

On the use of nanotechnology-based strategies for association of complex matrices from plant extracts

Formation of Nanocarrier Systems by Dense Gas Processing

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