Abstract:Sickle cell disease (SCD) is a mortal chronic disease caused by a point mutation in the ? chain gene in the hemoglobin A (HbA) molecule. Erythrocyte polymerization in SCD is mostly seen as a result of the decrease in the amount of ions and water in the cell, i.e. dehydration and deoxygenation of erythrocytes. Deoxygenated and dehydrated erythrocytes become susceptible to clustering, causing clogging of blood vessels which then leads to crisis. Therefore, development of a new treatment method that can effective… Show more
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