Preparation of isometric Liesegang patterns and application in multi-pulsed drug release system

Ni, Henmei; Pan, Mingzhen; Shi, Kai; Zhou, Junhu; Wu, Min

doi:10.1007/s10971-019-04931-6

Cited by 6 publications

(12 citation statements)

References 33 publications

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“…It was also presented that the periodic precipitation structure can be used to generate a stepwise kinetic curve of enzymolysis due to the banded structure of the pattern providing a new concept in multipulsed drug delivery. 114 A new perspective can also be the pattern design using stretchable media. It was recently shown that a periodic mechanical deformation in time for a polyacrylamide hydrogel medium can be used to generate equidistant patterns in 2D and 3D.…”

Section: ■ Application Of the Liesegang Phenomenon And Outlookmentioning

confidence: 99%

“…The existence of this threshold is a key ingredient in producing spatially periodic precipitation structures in either ionic or nanoscopic systems. It was also presented that the periodic precipitation structure can be used to generate a stepwise kinetic curve of enzymolysis due to the banded structure of the pattern providing a new concept in multipulsed drug delivery . A new perspective can also be the pattern design using stretchable media.…”

Section: Application Of the Liesegang Phenomenon And Outlookmentioning

confidence: 99%

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Pattern Formation in Precipitation Reactions: The Liesegang Phenomenon

2019

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Pattern formation is a frequent phenomenon in physics, chemistry, biology, and materials science. Bottom-up pattern formation usually occurs in the interaction of the transport phenomena of chemical species with their chemical reaction. The oldest pattern formation is the Liesegang phenomenon (or periodic precipitation), which was discovered and described in 1896 by Raphael Edward Liesegang, who was a German chemist and photographer who was born 150 years ago. The purpose of this feature article is to provide a comprehensive overview of this type of pattern formation. Liesegang banding occurs because of the coupling of the diffusion process of the reagents with their chemical reactions in solid hydrogels. We will discuss several phenomena observed and discovered in the past century, including reverse patterns, precipitation patterns with dissolution (due to complex formation), helicoidal patterns, and precipitation waves. Additionally, we will review all existing models of the Liesegang phenomenon including pre- and postnucleation scenarios. Finally, we will highlight several applications of periodic precipitation.

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Section: ■ Application Of the Liesegang Phenomenon And Outlookmentioning

confidence: 99%

Section: Application Of the Liesegang Phenomenon And Outlookmentioning

confidence: 99%

Pattern Formation in Precipitation Reactions: The Liesegang Phenomenon

2019

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“…The negative ions of hydrogen phosphate were then added to mineralize the SEV to obtain a nongenetically modified virus-inorganic nanohybrid ((SEV + ICG)@CaHPO 4 ) with synergistic immunotherapy for tumors. Therefore, the main component of the inorganic shell is calcium hydrogen phosphate, which is often used to supplement the lack of calcium and phosphorus in the body . Transmission electron microscopy (TEM) and dynamic light scattering were employed to characterize the shape and size of these bio-inorganic nanohybrids.…”

Section: Resultsmentioning

confidence: 72%

“…Therefore, the main component of the inorganic shell is calcium hydrogen phosphate, which is often used to supplement the lack of calcium and phosphorus in the body. 35 Transmission electron microscopy (TEM) and dynamic light scattering were employed to characterize the shape and size of these bio-inorganic nanohybrids. The results exhibited that the particle size of the virus and ICG after biomineralization was about 215 nm (PDI = 0.22), and the morphology was relatively uniform (Figure 2a,b).…”

Section: ■ Results and Discussionmentioning

confidence: 78%

Bio-Inorganic Hybrid Nongenetically Modified Viruses as an Immune Agonist for Systemic Elimination of Cancer Cells

Zheng

Huang

et al. 2020

ACS Appl. Mater. Interfaces

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Microbial-based cancer therapy is nowadays considered as an interesting approach, especially with viruses which are attracting more attention owing to their simple structure and nanoscale. However, because of the need for cumbersome genetic modification and poor biosafety, its application is seriously limited. Here, nonpathogenic natural Sendai viruses (SEVs) are used as an alternative immune agonist after being mineralized by calcium ions. Both in vitro and in vivo studies indicated that virus-inorganic hybrids can effectively excite antigen-presenting cells (APCs). Then, the tumor antigens were released in large amounts by photothermal damage. Meanwhile, these released antigens were presented to lymph nodes to mature antitumor T lymphocytes via the peritumoral APCs previously recruited by the SEV. Our results demonstrated that even after administration at one point, the nanohybrids could still effectively stimulate systemic antitumor immune response to suppress the potential cancer metastatic spread. The bio-inorganic hybrid nongenetically modified virus-inorganic nanocomposites might serve as an alternative strategy for synergistic immune therapy.

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“…Chemical organization via periodic precipitation offers a new strategy for the generation of materials with ordered morphologies and structural hierarchy (17,18). Molecular self-organization on nanoto micrometer length scales via the reaction-diffusion process has already led to proof-of-concept applications of periodically structured materials in optics (19), microfluidics (20), and drug release systems (21). An emerging frontier in this field is the design of reactiondiffusion systems in which the precipitation partners are nanocolloidal building blocks or a combination of NPs and molecules (4) rather than reacting molecules.…”

Section: Introductionmentioning

confidence: 99%

Self-organization of nanoparticles and molecules in periodic Liesegang-type structures

Ackroyd

Holló²,

Mundoor

et al. 2021

Sci. Adv.

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Chemical organization in reaction-diffusion systems offers a strategy for the generation of materials with ordered morphologies and structural hierarchy. Periodic structures are formed by either molecules or nanoparticles. On the premise of new directing factors and materials, an emerging frontier is the design of systems in which the precipitation partners are nanoparticles and molecules. We show that solvent evaporation from a suspension of cellulose nanocrystals (CNCs) and l-(+)-tartaric acid [l-(+)-TA] causes phase separation and precipitation, which, being coupled with a reaction/diffusion, results in rhythmic alternation of CNC-rich and l-(+)-TA–rich rings. The CNC-rich regions have a cholesteric structure, while the l-(+)-TA–rich bands are formed by radially aligned elongated bundles. The moving edge of the pattern propagates with a finite constant velocity, which enables control of periodicity by varying film preparation conditions. This work expands knowledge about self-organizing reaction-diffusion systems and offers a strategy for the design of self-organizing materials.

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Preparation of isometric Liesegang patterns and application in multi-pulsed drug release system

Cited by 6 publications

References 33 publications

Pattern Formation in Precipitation Reactions: The Liesegang Phenomenon

Pattern Formation in Precipitation Reactions: The Liesegang Phenomenon

Bio-Inorganic Hybrid Nongenetically Modified Viruses as an Immune Agonist for Systemic Elimination of Cancer Cells

Self-organization of nanoparticles and molecules in periodic Liesegang-type structures

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