1993
DOI: 10.1159/000462440
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Preparation of Intermediate- Purity Factor VIII Concentrate by Direct Gel Filtration of Cryoprecipitate

Abstract: We report a new method to produce a solvent/detergent-treated and severe dry heat-treated factor VIII (FVIII) concentrate (3-6 IU FVIII:C/mg protein). This method, which uses a single purification step after cryoprecip- itation, is suitable for scale-up to production levels. FVIII was obtained from solvent/detergent-treated cryoprecipitate by a single gel filtration step using Sephacryl S-400HR. The freeze-dried product was stable to heating at 80°C for 72 h. The yield of the solvent/detergent and severe dry h… Show more

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