Preparation of injectable hydrogels from temperature and pH responsive grafted chitosan with tuned gelation temperature suitable for tumor acidic environment

Jommanee, Natnicha; Chanthad, Chalathorn; Manokruang, Kiattikhun

doi:10.1016/j.carbpol.2018.06.099

Cited by 73 publications

(40 citation statements)

References 43 publications

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“…Moreover, by adjusting the release response mechanism and release rate of drugs under different stimuli, the nanocarriers can control the sequence and time schedule of drug combination therapy, so as to achieve more accurate drug delivery process and improve the effect and specificity of combined action . The drug release behavior can be realized in different stimulant responses in tumor therapy, such as pH (Wang et al, 2017), hypoxia (Kumari et al, 2020), reduction (Xie and Liu, 2020), enzyme (Shan et al, 2019), temperature (Jommanee et al, 2018), ultrasound (Xia et al, 2018), etc.…”

Section: Taking Advantage Of Analogs Of Celastrolmentioning

confidence: 99%

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Shi

et al. 2020

Front. Pharmacol.

113

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Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits significant broad-spectrum anticancer activities for the treatment of a variety of cancers including liver cancer, breast cancer, prostate tumor, multiple myeloma, glioma, etc. However, the poor water stability, low bioavailability, narrow therapeutic window, and undesired side effects greatly limit its clinical application. To address this issue, some strategies were employed to improve the anticancer efficacy and reduce the side-effects of celastrol. The present review comprehensively focuses on the various challenges associated with the anticancer efficiency and drug delivery of celastrol, and the useful approaches including combination therapy, structural derivatives and nano/micro-systems development. The specific advantages for the use of celastrol mediated by these strategies are presented. Moreover, the challenges and future research directions are also discussed. Based on this review, it would provide a reference to develop a natural anticancer compound for cancer treatment.

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Section: Taking Advantage Of Analogs Of Celastrolmentioning

confidence: 99%

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Shi

et al. 2020

Front. Pharmacol.

113

View full text Add to dashboard Cite

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“…In this work, they were able to modulate the sol-gel transition temperature and pH values of the systems to correspond to the conditions of acidic tumors. It was found that these systems may release doxorubicin and curcumin for a sustained period of up to two weeks [ 136 ]. As a final example, hydrogels have also been grafted onto alginate-based polymers; for instance, in a 2019 research paper by Iatridi and collaborators, a PNIPAM and N- tert -butylacrylamide were researched for the temperature dependence of their sol-gel transitions [ 137 ].…”

Section: Grafted Hydrogel Chainsmentioning

confidence: 99%

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

et al. 2020

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Hydrogels are materials with wide applications in several fields, including the biomedical and pharmaceutical industries. Their properties such as the capacity of absorbing great amounts of aqueous solutions without losing shape and mechanical properties, as well as loading drugs of different nature, including hydrophobic ones and biomolecules, give an idea of their versatility and promising demand. As they have been explored in a great number of studies for years, many routes of synthesis have been developed, especially for chemical/permanent hydrogels. In the same way, stimuli-responsive hydrogels, also known as intelligent materials, have been explored too, enhancing the regulation of properties such as targeting and drug release. By controlling the particle size, hydrogel on the micro- and nanoscale have been studied likewise and have increased, even more, the possibilities for applications of the so-called XXI century materials. In this paper, we aimed to produce an overview of the recent studies concerning methods of synthesis, biomedical, and pharmaceutical applications of macro-, micro, and nanogels.

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“…Chitosan has some unique features such as biocompatibility, biodegradability, non-toxicity, and complexing with metal ions [4]. Therefore, it is exploited universally in various applications such as in pharmaceuticals [5], the food industry [6], and water remediation [7]. Furthermore, the surface groups, namely, hydroxyl and amino groups, contribute to the hydrophilicity and active adsorption sites of Cs [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of Chitosan Addition on Resorcinol–Formaldehyde Xerogel Structure

Awadallah‐F

Al‐Muhtaseb

2019

Applied Sciences

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Gels are usually not environment-friendly due to their difficult biodegradability. Therefore, the addition of chitosan, even in small amounts, will make such gels biodegradable and thus can be useful in many applications that require environment-friendly materials. The addition of small quantities of chitosan to the reacting solution resorcinol–formaldehyde xerogel was investigated. Different hybrid resorcinol–formaldehyde–chitosan xerogels were characterized by different techniques, including Raman spectra, FTIR, XRD, TGA, SEM, surface area and porosity analyzer, and CHNS/O microanalyzer. It was seen that the addition of chitosan, even in a minor quantity, has a significant influence on the structural features of the resulting xerogels. The lattice order and crystallinity, chemical functions, thermal stability, morphology, elemental ratio, pore structure, and appearance were changed by adding chitosan into the xerogel structure.

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Preparation of injectable hydrogels from temperature and pH responsive grafted chitosan with tuned gelation temperature suitable for tumor acidic environment

Cited by 73 publications

References 43 publications

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

Influence of Chitosan Addition on Resorcinol–Formaldehyde Xerogel Structure

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