Preparation of (S)‐ibuprofen‐imprinted polymer and its molecular recognition study

Abstract

Two molecularly imprinted polymers (MIPs) were prepared using (S)-ibuprofen as the template molecule as well as methacrylic acid (MAA) or 4-vinylpyridine and ethylene glycol dimethacrylate (EGDMA) as the functional monomer and crosslinker, respectively. Free radical polymerization was carried out at 4 degrees C under ultraviolet (UV) radiation. The MIPs thus obtained were ground into 25-44 mu m, which were slurry packed into analytical columns. The template molecules were removed by acetic acid/methanol solution (1:9, v/v). high-performance liquid chromatography (HPLC), with UV detection, was used to evaluate the binding performance of the MIP for the template. The selectivity of (S)-ibuprofen and naproxen on the host-guest system were assessed using acetonitrile-based mobile phases. The limits of detection of ibuprofen and naproxen were found to be 0.1844 mmol/L and 0.3264 mmol/L, while the limits of quantitation were 0.6262 mmol/L and 1.0909 mmol/L, respectively. The stationary phase was applied successfully to the commercial tablet analysis. Ibuprofen and naproxen were extracted from tablets with acetonitrile; analysis results showed a good relative standard deviation (RSD) of 0.81-1.24% and accuracy from -4.01 to +2.98% for ibuprofen as well as an RSD of 0.59-0.86% and accuracy from -4.01 to -2.01% for naproxen. (c) 2006 Wiley Periodicals, Inc

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

“…The demonstration of template (or template analog)‐selective recognition by an MIP remains a cornerstone in the development of all new MIP systems. Various strategies have been employed to characterize ligand‐polymer binding events,…”

High Affinity Polymers by Molecular Imprinting for Drug Delivery

“…They are cheap to synthesize and can be manufactured in large quantities with good reproducibility. These properties explain the growing interest in imprinted materials in the last decades, resulting in a significant increase in reported works in such diverse areas as in synthesis and catalysis [14,15], solidphase extraction [16,17], chromatography [18,19], sensing [20,21] and in drug delivery [22,23].…”

Synthesis and adsorption properties of carbamazepine imprinted polymer by dispersion polymerization in supercritical carbon dioxide

“…The studies about of molecular imprinting actively have continued enabling molecularly imprinted polymers (MIPs) to facilitate the synthesis, to secure good physical properties, and to give them economic advantages [10][11][12][13][14][15][16]. Subsequently, it has been applied for chromatographic fillers [17], artificial enzymes [18,19], and high-efficiency bio-sensor [20]. MIPs are synthesized with template which is selectively combined with the functional monomer and crosslinking agents.…”