Preparation of (<i>S</i>)-Cyanohydrins by Enantioselective Cleavage of Racemic Cyanohydrins with (<i>R</i>)-Hydroxynitrile Lyase

Effenberger, Franz; Schwämmle, Achim

doi:10.3109/10242429709106884

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Enzymes Used For Carbon‐carbon Bond Formation1

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2013

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Cited by 18 publications

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“…Employing a biphasic system, namely citrate buffer/diisopropyl ether (40:1) at 39 °C, catalytic amounts of PhNH2 and semicarbazide were added for aldehyde capture. In this manner the ( S )‐cyanohydrin of 3‐phenoxybenzaldehyde was obtained with 91 % ee at 50 % conversion 166. Almond meal was used for the resolution of rac ‐2‐hydroxy‐2‐phenylpropanenitrile.…”

Section: Enzymes Used For Carbon‐carbon Bond Formationmentioning

confidence: 99%

Biocatalytic Methods for CC Bond Formation

2013

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Carbon‐carbon bond formation is among the most challenging transformations in the organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest. The enzymes for stereoselective CC bond formations have been investigated very intensively during the last two decades. New recombinant DNA technologies have paved the way for improved catalysts and broaden the application scope of the already known enzymes and reactions. On the other side new discoveries have brought more enzyme players in the arena of CC bond formation reactions. Novel enzymatic CC bond formation reactions have been applied, implying the most important benefit of biocatalysis, namely the high selectivity.

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Section: Enzymes Used For Carbon‐carbon Bond Formationmentioning

confidence: 99%