Preparation ofN-Tosylaldimines

Cu(OTf)2andN-Sulfinylprolinamide Catalyzed Friedel-Crafts Reaction of Indoles withN-Sulfonylaldimines

“…[15,16] 、N-甲基吲哚 [17] 、N-叔丁基亚磺 酰基脯氨酰胺(L) [10] (所用到的脯氨酸和叔丁基亚磺酰胺 都为消旋化合物)均按文献方法合成. 143.98, 136.65, 128.69, 128.19, 127.05, 126.10, 123.58, 121.88, 119.90, 119.66, 119.20, 111.01, 40.17. 3.2.3 产物 3a～3r 的合成 N 2 保护下, 向 25 mL 的反应管中加入 Cu(OTf) 2 (0.018 g, 0.5 mmol)、 L (0.016 g, 0.0075 mmol)、 CH 2 Cl 2 (3 mL), 室温下搅拌反应 2 h. 随后待温度降至 0 ℃, 将吲 哚类化合物 1 (2.5 mmol)和 N-磺酰醛亚胺 2 (0.5 mmol) 的 CH 2 Cl 2 (2 mL)溶液用注射器注入反应管中, 薄层色 谱监测至 2 转化完全, 通常需要 3～18 h. 反应液直接用 饱和食盐水(10 mL×2)洗涤, 有机相用无水 Na 2 SO 4 干 燥, 粗产物由柱层析纯化(硅胶, V 石油醚∶V 乙酸乙酯＝10∶1) 得到化合物 3a～3r.…”

Asymmetric Aza‐MoritaBaylisHillman Reaction of N‐Sulfonated Imines with Methyl Vinyl Ketone Catalyzed by Chiral Phosphine Lewis Bases Bearing Perfluoroalkanes as “Pony Tails”

“…N-Sulfonated imines 1 were prepared according to the literature. [16] Commercially obtained reagents were used without further purification. All reactions were monitored by TLC with Huanghai GF 254 silica gel coated plates.…”

Aza‐Baylis–Hillman Reaction of β‐Substituted Activated Olefins with N‐Tosyl Imines

“…Co. and used without purification. All N-tosyl imines [7] and (E)-propenyl phenyl ketone [8] were prepared according to the literature. Infrared spectra were measured on a Perkin-Elmer 983 spectrometer.…”