Preparation of N-Maleoylchitosan Nanocapsules for Loading and Sustained Release of Felodipine

Abstract

An interfacial free radical polymerization method was developed to fabricate polysaccharide nanocapsules, in which poor water-soluble drug of felodipine could be effectively encapsulated with good stability during storage. Exemplified by the preparation of felodipine-loaded N-maleoylchitosan (NMCS) nanocapsules, a felodipine/chloroform mixture was dispersed in NMCS aqueous solution with the aid of a nonionic surface active agent. After charging initiator, the vinylated groups of NMCS were polymerized on the oil-water interface. As a result, felodipine was loaded into NMCS nanocapsule. The morphology and the size distribution of synthesized nanocapsules were characterized by field emission scanning electron microscopy (FESEM) and dynamic light scattering (DLS) techniques. The quantitative drug loading and sustained release behavior were investigated. The encapsulation efficiency and drug loading content were found to be strongly dependent on the feed felodipine concentration. The release dynamics showed strong correlation with the degree of maleoyl substitution and the feed NMCS concentration during the course of nanocapsules preparation.

Optimization of Formulation Variables Affecting Spray-Dried Oily Core Nanocapsules by Response Surface Methodology

“…Also, by increasing the oil amount, the diameter of NCs also increases, thus reducing the total surface of the oily core. Previously, a correlation was observed between maximal encapsulation of hydrophobic drug and the total surface of oily core, 46 which suggested that a lower oil amount would have higher EE%. Figures 4a and 4b show two typical threedimensional response surface plots of the interactions between formulation variables.…”

“…It is reasonably speculated that micelles of surfactant and IND outside of polymer-encapsulated NCs are formed when the surfactant level is high and the PLA level is low, leading to relatively lower EE% as shown in Figure 4b. On the basis of other studies with the effect of drug molecule hydrophobicity and its encapsulation in NCs, 45,46 future studies are needed to elucidate the exact location of the drug molecules within this type of nanosystem (within the shell or fully in the oily core or in both the core and the shell).…”

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

“…(Scheme S1). 33 In a typical synthesis, chondroitin sulfate powder (1.0 g) was first dissolved in 100 mL aqueous solution and transferred to a three necked flask. The maleic anhydride (MA) were dissolved in 5 mL of acetone, and then the maleic anhydrideacetone solution was added to the reaction flask drop wise over 20 min at 65°C.…”

Synthesis and characterization of polybutylcyanoacrylate‐encapsulated rose fragrance nanocapsule

“…Many researches in the field of biology and medicines have indicated that nanocapsules have sustained-release properties. [21][22][23] For textiles, this nanocapsule's special structure can ensure that the nanocapsules penetrate into the holes between cotton fibres easily and are then fixed onto the cotton fibres. It can also be concluded from the existing researches that there are few instances of polymeric materials-encapsulated fragrance nanocapsules.…”

“…Nanocapsules are materials containing a polymeric shell and an oil core, and their size is controlled to <100 nm. Many researches in the field of biology and medicines have indicated that nanocapsules have sustained‐release properties . For textiles, this nanocapsule's special structure can ensure that the nanocapsules penetrate into the holes between cotton fibres easily and are then fixed onto the cotton fibres.…”