Preparation of hydroxypropyl methyl cellulose phthalate nanoparticles with mixed solvent using supercritical antisolvent process and its application in co-precipitation of insulin

Jin, He; Xia, Fei; Zhao, Ya

doi:10.1016/j.apt.2011.01.007

Cited by 37 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, SCF is used as an antisolvent that causes precipitation of the protein. Several examples of nano‐ and micro‐particles have been reported, including insulin and α‐chymotrypsin, although varying degrees of stability have been reported. SAS processes have also been considered for the production of protein‐loaded microparticles by co‐precipitation of the biodegradable polymer and the protein from an organic cosolvent .…”

Section: Supercritical Dryingmentioning

confidence: 99%

Next Generation Drying Technologies for Pharmaceutical Applications

Walters

Bhatnagar

Tchessalov

et al. 2014

Journal of Pharmaceutical Sciences

177

View full text Add to dashboard Cite

Section: Supercritical Dryingmentioning

confidence: 99%

Next Generation Drying Technologies for Pharmaceutical Applications

Walters

Bhatnagar

Tchessalov

et al. 2014

Journal of Pharmaceutical Sciences

177

View full text Add to dashboard Cite

“…A mixed solvent method was employed to enable the simultaneous achievement of facilitated preparation for nanoscale particles, 38 and a high concentration of a hydrophobic drug (etoposide) could be made since ethanol was involved. Citric acid was used here as a crystal modifier to control the selectivity of polymorph and crystal morphology during the process of mineralization.…”

Section: Resultsmentioning

confidence: 99%

pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release

Qian¹,

Sun²,

Zhu³

et al. 2012

IJN

View full text Add to dashboard Cite

Strontium carbonate nanoparticles (SCNs), a novel biodegradable nanosystem for the pH-sensitive release of anticancer drugs, were developed via a facile mixed solvent method aimed at creating smart drug delivery in acidic conditions, particularly in tumor environments. Structural characterization of SCNs revealed that the engineered nanocarriers were uniform in size and presented a dumbbell-shaped morphology with a dense mass of a scale-like spine coating, which could serve as the storage structure for hydrophobic drugs. Chosen as a model anticancer agent, etoposide was effectively loaded into SCNs based on a simultaneous process that allowed for the formation of the nanocarriers and for drug storage to be accomplished in a single step. The etoposide-loaded SCNs (ESCNs) possess both a high loading capacity and efficient encapsulation. It was found that the cumulative release of etoposide from ESCNs is acid-dependent, and that the release rate is slow at a pH of 7.4; this rate increases significantly at low pH levels (5.8, 3.0). Meanwhile, it was also found that the blank SCNs were almost nontoxic to normal cells, and ESCN systems were evidently more potent in antitumor activity compared with free etoposide, as confirmed by a cytotoxicity test using an MTT assay and an apoptosis test with fluorescence-activated cell sorter (FACS) analysis. These findings suggest that SCNs hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy.

show abstract

“…62 Regenerated pure cellulose nanospheres were prepared from analogous processes using cellulose solutions, such as 50% w/w n-methylmorpholine-n-oxide, and NaOH/urea, while the supercritical antisolvent (SAS) process, based on the nanoprecipitation mechanism, was employed to prepare derivatized cellulose nanospheres. [38][39][40]63 Wondraczek et al compared conventional solvent evaporation with nanoprecipitation by characterizing the resulting nanospheres. 19 Both methods produced narrow reproducible dispersions of spherical nanoparticles.…”

Section: Dispersion-based Methods For Cellulose Nanoparticle Preparationmentioning

confidence: 99%

“…13,19,[21][22][23][24][25][26][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][62][63][64] Size distribution is particularly important, since narrower distributions favor control of secondary properties such as controllable release rates. Successful nanosphere applications meeting expected performance criteria require largely empirical correlations between measured particle properties and responses in specific applications.…”

Section: Evaluation Of Cellulose-based Nanospheresmentioning

confidence: 99%

Cellulose/Cellulose-Based Nanospheres: Perspectives and Prospective

Fei

WinterWilliam

2015

Industrial Biotechnology

View full text Add to dashboard Cite

Spherical nanoparticles are attracting increasing interest for diverse commercial uses due to their many useful attributes such as applicability as controlled-release systems and their super-hydrophobicity. In this review, methods of particle formation for cellulose, its derivatives, and related species are discussed with reference to numerous specific examples. Techniques for characterization of particle size, size-distribution, and related properties under both dispersed and solid particle conditions are summarized and contrasted. Finally, we note potential applications for these surprisingly reproducible nanospheres.

show abstract

Preparation of hydroxypropyl methyl cellulose phthalate nanoparticles with mixed solvent using supercritical antisolvent process and its application in co-precipitation of insulin

Cited by 37 publications

References 25 publications

Next Generation Drying Technologies for Pharmaceutical Applications

Next Generation Drying Technologies for Pharmaceutical Applications

pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release

Cellulose/Cellulose-Based Nanospheres: Perspectives and Prospective

Contact Info

Product

Resources

About