Preparation of hydroxyapatite–ferrite composite particles by ultrasonic spray pyrolysis

Abstract

a b s t r a c tBio-compatible composite particles composed of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAp) and ferrite (maghemite (␥-Fe 2 O 3 ) or magnetite (Fe 3 O 4 )) were synthesized by two-step synthesis. In this work, coprecipitation method using aqueous solution of FeSO 4 and FeCl 3 was employed to synthesize ␥-Fe 2 O 3 and Fe 3 O 4 particles. It was found that the resultant phase was changed by the molar ratio of FeSO 4 and FeCl 3 , and optimal molar ratio to suppress the coexistence of ␣-FeOOH was FeSO 4 /FeCl 3 = 2. The suspension composed of crushed ferrite particles, Ca(NO 3 ) 2 and H 3 PO 4 aqueous solution with surfactant ultrasonically nebulized into mist and the mist was pyrolyzed at 500 • C to synthesize HAp-ferrite composite particles. The shape of the synthesized composite particle was round with dimple, and the particle size was around 0.5-3 m in diameter. The composite particle showed saturation magnetization of 0.833 emu/g. Net saturation magnetization of the ferrite component was calculated to be 46.4 or 48.0 emu/g under the assumption that the ferrite was composed of ␥-Fe 2 O 3 or Fe 3 O 4 , respectively.

Synthesis and hyperthermia property of hydroxyapatite–ferrite hybrid particles by ultrasonic spray pyrolysis

“…(1) In our previous work [17], it was found that considerable amount of a-FeOOH was coexisted with Fe 3 O 4 and g-Fe 2 O 3 in the case of x ¼33.3. It was also found that the amounts of Fe 3 O 4 and g-Fe 2 O 3 were increased and that of a-FeOOH was decreased with x.…”

“…Many studies have examined HAp fabrication [15,16]. Previously, we reported the synthesis of HAp-ferrite composite particles [17]. However, it has a very low magnetic property (saturation magnetization is 0.833 emu/g).…”

Controlled Preparation and Formation Mechanism of Hydroxyapatite Nanoparticles under Different Hydrothermal Conditions

“…HAP exists as nanorods in the bone. Many methods have been employed for the synthesis of fine particles with controlled particle size and shape, such as dry processes [9] , precipitation [10] , solegel [11] , spray pyrolysis [12] , emulsion system [13,14] , solvothermal synthesis [15,16] , sonochemical synthesis [17] and others [18e20] . Hydrothermal reaction is a green and conventional method to prepare HAP materials, but usually with poor control on particle size and shape.…”

Synthesis and Characterization of Magnetic-Hydroxy Apatite Composite Usingone Spot Coprecipitation Method

“…Two-steps method is carried out in which magnetic nanoparticle and HAP separately synthesized before mixing them to form composite. This synthesis route is performed using microemulsion [2], hydrothermal [4], mechanochemical process [5], and spray drying or spray pyrolysis technique [7,8]. All these processes usually result in the formation of hundreds size of composite particles having low magnetization value due to high fraction of HAP within the composite.…”