Preparation of highly monodisperse W/O emulsions with hydrophobically modified SPG membranes

Cheng, Chang-Jing; Chu, Liang‐Yin; Xie, Rui

doi:10.1016/j.jcis.2006.03.056

Cited by 65 publications

(47 citation statements)

References 34 publications

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“…The mean particle size was expressed as the number-average mean diameter, d av and the polydispersity was expressed as the coefficient of variation, CV = (σ/d av ) × 100, where σ is the standard deviation of particle diameters in a suspension. A smaller CV or PDI value indicates the narrower size distribution [20,21]. All values of the mean particle size and PDI or CV are expressed as the mean ± standard deviation (S.D.…”

Section: Characterization Of Liposomesmentioning

confidence: 99%

Preparation of liposomes: a novel application of microengineered membranes - investigation of the process parameters and application to the encapsulation of vitamin E

et al. 2013

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Liposomes with a mean size of 59-308 nm suitable for pulmonary drug delivery were prepared by the ethanol injection method using nickel microengineered flat disc membranes with a uniform pore size of 5-40 mm and a pore spacing of 80 or 200 mm. An ethanolic phase containing 20-50 mg ml 21 phospholipid (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or Lipoid1 E80), 5-12.5 mg ml 21 stabilizer (cholesterol, stearic acid or cocoa butter), and 0 or 5 mg ml 21 vitamin E was injected through the membrane into an agitated aqueous phase at a controlled flux of 142-355 l m 22 h 21 and a shear stress on the membrane surface of 0.80-16 Pa. The mean particle size obtained under optimal conditions was 84 and 59 nm for Lipoid E80 and POPC liposomes, respectively. The particle size of the prepared liposomes increased with an increase in the pore size of the membrane and decreased with an increase in the pore spacing. Lipoid E80 liposomes stabilized by cholesterol or stearic acid maintained their initial size within 3 months. A high entrapment efficiency of 99.87% was achieved when Lipoid E80 liposomes were loaded with vitamin E. Transmission electron microscopy images revealed spherical multi-lamellar structure of vesicles. The reproducibility of the developed fabrication method was high.

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Section: Characterization Of Liposomesmentioning

confidence: 99%

Preparation of liposomes: a novel application of microengineered membranes - investigation of the process parameters and application to the encapsulation of vitamin E

et al. 2013

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“…Hydrophobic membranes are needed to produce water-in-oil (W/O) (Cheng et al, 2008;Jing et al, 2006) and oil-in-water-in-oil (O/W/O) (Wei et al, 2013) emulsions and hydrophilic membranes are required to prepare oil-in-water (O/W) and water-in-oil-in-water (W/O/W) (Vladisavljević et al, 2014) emulsions. The advantages of PME over DME are in smaller droplet sizes and higher transmembrane fluxes that can be achieved for any given pore size and higher dispersed phase content that can be obtained (up to 60 vol% in simple PME and up to 90 vol% in PME with phase inversion (Suzuki et al, 1999)).…”

Section: Membrane Emulsificationmentioning

confidence: 99%

“…In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (Suzuki et al, 1996) or a packed bed of uniform particles (van der Zwan et al, 2008;Yasuda et al, 2010;Laouini et al, 2014), which leads to homogenisation of existing coarse droplets. If the transmembrane pressure is lower than the capillary pressure, the pressure force acting on a droplet will not be able to squeeze the droplet through a pore, which will lead to the separation of the pre-emulsion into a dropletfree continuous phase and concentrated emulsion (Koltuniewicz et al, 1995; Park et al, 1998).Hydrophobic membranes are needed to produce water-in-oil (W/O) (Cheng et al, 2008;Jing et al, 2006) and oil-in-water-in-oil (O/W/O) (Wei et al, 2013) emulsions and hydrophilic membranes are required to prepare oil-in-water (O/W) and water-in-oil-in-water (W/O/W) (Vladisavljević et al, 2014) emulsions. The advantages of PME over DME are in smaller droplet sizes and higher transmembrane fluxes that can be achieved for any given pore size and higher dispersed phase content that can be obtained (up to 60 vol% in simple PME and up to 90 vol% in PME with phase inversion (Suzuki et al, 1999)).…”

mentioning

confidence: 99%

Structured microparticles with tailored properties produced by membrane emulsification

Vladisavljević

2015

Advances in Colloid and Interface Science

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This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, multilayer, and Pickering emulsions can be produced with high encapsulation efficiency of encapsulated materials and narrow size distribution and transformed into structured particles using a variety of different processes, such as polymerisation (suspension, mini-emulsion, interfacial and in-situ), ionic gelation, chemical crosslinking, melt solidification, internal phase separation, layer-by-layer electrostatic deposition, particle self-assembly, complex coacervation, spray drying, sol-gel processing, and molecular imprinting. Particles fabricated from droplets produced by membrane emulsification include nanoclusters, colloidosomes, carbon aerogel particles, nanoshells, polymeric (molecularly imprinted, hypercrosslinked, Janus and core/shell) particles, solder metal powders and inorganic particles. Membrane 2 emulsification devices operate under constant temperature due to low shear rates on the membrane surface, which range from (1−10) × 10 3 s −1 in a direct process to (1−10) × 10 4 s −1 in a premix process.Keywords: Membrane Emulsification; Polymeric microsphere; Microgel; Janus Particle; Core/Shell Particle, Colloidosome. Membrane emulsificationMembrane emulsification (ME) involves preparation of emulsions by pressing a pure dispersed phase or pre-emulsified mixture of the dispersed and continuous phase through a microporous membrane under controlled injection rate and shear conditions. In direct membrane emulsification (DME), one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al., 1991;, which leads to the formation of droplets at the membrane/continuous phase interface ( Figure 1a). In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (...

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“…In DME, one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al, 1991) leading to the formation of droplets at the membrane/continuous phase interface (Figure 2a). Hydrophobic membranes are needed to produce water-in-oil (W/O) emulsions (Cheng et al, 2008;Jing et al, 2006), and hydrophilic membranes are required to prepare oilin-water (O/W) emulsions (Figure 2a). In membrane microbubbling, a pressurised gas is forced through a hydrophilic membrane into aqueous continuous phase, leading to the formation of microbubbles (1 m < d bubble < 1 mm) or nanobubbles (d bubble <1 m), depending on the pore size of the membrane (Figure 2b).…”

Section: Membrane Dispersion Processesmentioning

confidence: 99%

High-pressure Homogenizer Design

Rayner¹

2015

Engineering Aspects of Food Emulsification and Homogenization

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Preparation of highly monodisperse W/O emulsions with hydrophobically modified SPG membranes

Cited by 65 publications

References 34 publications

Preparation of liposomes: a novel application of microengineered membranes - investigation of the process parameters and application to the encapsulation of vitamin E

Preparation of liposomes: a novel application of microengineered membranes - investigation of the process parameters and application to the encapsulation of vitamin E

Structured microparticles with tailored properties produced by membrane emulsification

High-pressure Homogenizer Design

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