Preparation of glycoside polymer micelles with antioxidant polyphenolic cores using alkylated poly(arbutin)s

Abstract

This paper describes the synthesis of long-chain-alkylated poly(arbutin)s (poly(Arb)-Rx, where R = alkyl-chain length and x = degree of substitution (DS)) and their aqueous micelle formation.

One-step synthesis of amphiphilic copolymers PDMS-b-PEG using tris(pentafluorophenyl)borane and subsequent study of encapsulation and release of curcumin

“…The CMC for PR12 was lower than for PR11 (1.5 g L −1 vs. 2.0 g L −1 ) which is due to the longer chain length containing three blocks compared to two blocks of PR11, which allows the formation of more stable micelles. 69…”

“…The CMC for PR12 was lower than for PR11 (1.5 g L À1 vs. 2.0 g L À1 ) which is due to the longer chain length containing three blocks compared to two blocks of PR11, which allows the formation of more stable micelles. 69 Size -DLS. Once the CMC of each BCP was obtained, the size of the micelles in an aqueous medium was calculated via dynamic light scattering (DLS).…”

Synthesis of Poly(thymol) via Oxidative Coupling Polymerization

“…Glycoside -arbutin (Arb) is one of the main polyphenol components in pears; recently, we reported the selective C-C oxidative polymerization of Arb using a conventional copper catalyst in a buffer solution to produce corresponding poly(arb) with M n values reaching 10 kDa [20]. In addition, we investigated the introduction of n-alkyl groups to poly(arb) via addition reactions between n-alkyl isocyanate and the phenolic group, which produces corresponding alkylated polymers [poly(arb)-R x ] (R: alkyl group, x: degree of substitution) [21]. Thymol, which is found in varying amounts in the essential oil of several plants belonging to the genera Thymus (Thyme), Origanum (Origanum), and Carum (Ajowan), is another naturally occurring phenol, which has been widely used to treat several helminth infections in people during the early periods of this century [22].…”