“…Silica mesoporous microspheres, which can be prepared by spray drying, polymerization–induced colloid aggregation (PICA), emulsion, template, sol–gel, and other methods [ 2 , 3 ], have physical stability, controllable particle size, no obvious cytotoxicity, good biocompatible performance, huge specific surface area and pore volume, excellent loading performance, uniform pore size, ordered arrangement, and controllable size and silanol groups [ 4 ]. Thanks to their unique properties, silica mesoporous microspheres exhibit promising applications in various fields, such as catalysis and drug delivery [ 5 , 6 , 7 , 8 ], liquid chromatography [ 9 , 10 , 11 , 12 ], heavy metal adsorption [ 13 , 14 , 15 ], functional coatings [ 16 , 17 ], and so on. Notably, in liquid chromatography, the stationary phase is primarily composed of silica microspheres, accounting for over 80%.…”