Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer

Kawashita, Masakazu; Tanaka, Masashi; Kokubo, Tadashi; Inoue, Yoshiaki; Yao, Takeshi; Hamada, Shota; Shinjo, Teruya

doi:10.1016/j.biomaterials.2004.07.014

Cited by 150 publications

(86 citation statements)

References 16 publications

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“…Ag 2 O SiO 2 glasses prepared by the solgel method are often yellow or brown in color, however, owing to the presence 19) and transmission electron micrographs of crosssections of the microspheres. 20) Fig.…”

Section: Antibacterial Ceramic Microspheresmentioning

confidence: 99%

Development and evaluation of the properties of functional ceramic microspheres for biomedical applications

Kawashita

2018

J. Ceram. Soc. Japan

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Radioactive or magnetic ceramic microspheres 2030¯m in diameter are useful for intra-arterial radiotherapy or hyperthermia. Antibacterial ceramic microspheres can provide antibacterial activity for biomedical polymers such as dental resin. Bioactive ceramic microspheres with drug load/release properties are useful, moreover, as inorganic fillers for bone cement and can also be used in chemoembolization therapy. The author introduces some successes and challenges associated with the development of functional ceramic microspheres for biomedical applications.

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Section: Antibacterial Ceramic Microspheresmentioning

confidence: 99%

Development and evaluation of the properties of functional ceramic microspheres for biomedical applications

Kawashita

2018

J. Ceram. Soc. Japan

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“…Fe 3 O 4 microspheres with a 20 30¯m diameter range were synthesized by melting the powder in a high frequency induction thermal plasma at high temperature and by precipitation from an aqueous solution. 15) As a conventional method, the preparation of microspheres was possible by a spray drying technique at low temperature using nanoparticles.…”

Section: )mentioning

confidence: 99%

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Aono

2014

J. Ceram. Soc. Japan

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Thermal coagulation therapy using powdered magnetic materials in an alternating (AC) magnetic field has been expected as a treatment of cancerous tissues. For nano-sized superparamagnetic particles, the magnetic energy is mainly converted to a heat generation ability by the rotation of the magnetic moment (Néel relaxation) along with the rotation of the particles (Brownian relaxation). Fe 3 O 4 (magnetite) nanoparticles have been mainly investigated as the candidate material for this type of therapy. In this review, an outline of the ferrite materials having heat generation ability in the AC magnetic field is described for the application of the thermal coagulation therapy. In particular, I focused on the preparation of a nano-sized magnetic material using physical bead milling to develop a magnetic material of Y 3 Fe 5 O 12 and its high heat generation ability. The preparation of Y 3 Fe 5 O 12 microspheres with a 2032¯m diameter range using the bead-milled powder was also described for the embolization method of cancer treatment.

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“…Various techniques for heating the tumors, such as treatments with hot water, infrared rays, ultrasound, and microwaves have been attempted. However, deep-seated tumors cannot be heated effectively and locally using these techniques (Kawashita et al, 2005). The biggest problem with this treatment is that it is not selective, i.e., when subjected to hyperthermia for tumor treatment, it also affects normal cells adjacent to the tumor.…”

Section: Magnetic Hyperthermiamentioning

confidence: 99%

Multifunctional Nanocomposites Based on Mesoporous Silica: Potential Applications in Biomedicine

Sousa¹,

Souza²,

Mohallem³

et al. 2011

Advances in Diverse Industrial Applications of Nanocomposites

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Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer

Cited by 150 publications

References 16 publications

Development and evaluation of the properties of functional ceramic microspheres for biomedical applications

Development and evaluation of the properties of functional ceramic microspheres for biomedical applications

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Multifunctional Nanocomposites Based on Mesoporous Silica: Potential Applications in Biomedicine

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