Preparation of fenofibrate nanoparticles by combined stirred media milling and ultrasonication method

Abstract

The production of fenofibrate nanoparticles combining stirred media milling and ultrasonication method was investigated in the current work. The fenofibrate drug sample was first wet milled in stirred media mill for different times and subsequently processed by ultrasonication. The effects of ultrasonication time, power on final product particle sizes were studied. The pre milling by stirred media milling was resulted into reduction of comminution resistance of material. Subsequent treatment by ultrasonication produced smaller particles than obtained by stirred media milling alone. The resulting nanoparticles were found to exhibit excellent stability as investigated by particle size, zeta potential, and multiple light scattering measurement techniques. Further, qualities of nanoparticles obtained by combined approach were characterized by TEM and XRD analysis.

Enhanced physical stabilization of fenofibrate nanosuspensions via wet co-milling with a superdisintegrant and an adsorbing polymer

“…[59,60], a similar characteristic peak intensity reduction for milled FNB was observed. The reduction in PXRD peak heights could again be attributed to defects generated at the particle surfaces and nanocrystalline nature of the material produced by the wet media milling [56,57,60]. All other FNB samples had similar diffractograms to that of the FNB wet-milled alone (F1).…”

An Intensified Vibratory Milling Process for Enhancing the Breakage Kinetics during the Preparation of Drug Nanosuspensions

“…This finding is not surprising because comprehensive characterization of the milled GF particles via DSC, XRD, and Raman spectroscopy demonstrated that even apparently more aggressive wet stirred media milling process did not cause notable change to the crystallinity (27,44). Moreover, similar observations were made for the crystallinity of other wet media milled, poorly water-soluble drugs such as fenofibrate (49)(50)(51) and indomethacin (44). Figure 6c illustrates the remarkably fast dissolution, i.e., complete dissolution within 2 min, in water for the vibratory milled GF (Run 13) in comparison to the slow dissolution of the as-received GF and GF in the physical mixture.…”

Formulation, Optimization, and in Vitro Evaluation of Polymeric Nanosuspension of Flurbiprofen

“…The formulation can be achieved by top-down (fracturing larger particles to smaller particles) or bottom-up (generation of smaller particles by precipitation at molecular level) approaches [1,[9][10][11][12][13]. Nanoprecipitation is one of the promising techniques for the development of nanosuspension of low water-soluble drug molecules [14]. However, particle agglomeration and crystal growth due to Van der Waals forces or Ostwald ripening can be prevented by addition of one or more stabilizer (s) [15].…”