Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting

Wang, Xiaomei; Chi, Na; Tang, Xing

doi:10.1016/j.ejpb.2008.07.005

Cited by 272 publications

(113 citation statements)

References 32 publications

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“…> BRC-loaded CS NPs (i.v. ), respectively, at 0.5 h are indicative of direct nose-to-brain transport bypassing the BBB, which in turn prove the superiority of nose-to-brain delivery of BRC-loaded CS NPs [29]. Selected pharmacokinetic parameters of i.n.…”

Section: Optimised Nanoformulation Of Brc For Direct Nose-to-brain Dementioning

confidence: 99%

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

Shadab

Haque

Fazil

et al. 2014

Expert Opinion on Drug Delivery

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Section: Optimised Nanoformulation Of Brc For Direct Nose-to-brain Dementioning

confidence: 99%

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

Shadab

Haque

Fazil

et al. 2014

Expert Opinion on Drug Delivery

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“…TMC nanoparticles are a potential new delivery system for protein transport through the nasal mucosa. 72 Wang et al, 73 who prepared estradiol-loaded chitosan nanoparticles and investigated the levels of estradiol in blood and cerebrospinal fluid in rats after intranasal administration, showed that estradiol levels in the cerebrospinal fluid after intranasal administration were significantly higher than after intravenous administration. The drug targeting index (DTI) of the nasal route was 3.2 and drug targeting percent (DTP%) was 68.4%.…”

Section: Routes Of Administrationmentioning

confidence: 99%

Recent advances of chitosan nanoparticles as drug carriers

Zeng¹

2011

IJN

253

124

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Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.

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“…Chitosan nanoparticles were prepared by ionic gelation of chitosan with STPP (Koukaras et al, 2012) (Wang et al, 2008). Different concentrations of chitosan (1-3 mg/ml) were dissolved in 1% v/v aqueous acetic solution and ZMT was dissolved in the solutions.…”

Section: Preparation Of Zmt Loaded Nanoparticlesmentioning

confidence: 99%

“…The amount of ZMT entrapped in chitosan nanoparticles was determined by indirect method (Wang et al, 2008). An aliquot of the supernatant containing the free drug was collected immediately after ultracentrifugation (412LAC, Remi Equipments, Mumbai, India) of nanosuspension and analyzed by UV spectrophotometry at 222 nm.…”

Section: Entrapment Efficiency (Ee)mentioning

confidence: 99%

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Mandlik

Ranpise

2017

Int Curr Pharm J

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The present study investigated the implementation of 32 factorial design of experiment and statistical analysis for the optimization of chitosan nanoparticles containing zolmitriptan an antimigraine drug. The influence of chitosan concentration (X1) and sodium tripoly phosphate (X2) on responses namely nanoparticle size (Y1), and entrapment efficiency (Y2), was studied. As per design, nine runs of nanoparticles were prepared by modified ionic gelation method using high speed vortex mixing. The particle size was found in the range of 151-880 nm and entrapment efficiency was 72.3-81.2%. A statistical analysis was performed using licensed design expert software V.8.0 with respect to ANOVA, regression analysis. The contour plots and response surface plots showed visual representation of relationship between the experimental responses and the set of independent variables. Regression model equations were validated by a numerical and graphical optimization method. Further, optimized drug loaded nanoparticles showed +23.7mV zeta potential indicating storage stability, electron micrograph reflects spherical shape and mixed type of drug release followed by Fickian diffusion (n=0.266) was observed. Thus, using systematic factorial design approach, desirable goals can be achieved in shortest possible time with lesser number of experiments which was proven to be an effective tool in quality by design.Mandlik and Ranpise, International Current Pharmaceutical Journal, February 2017, 6(3): 16-22http://www.icpjonline.com/documents/Vol6Issue3/01.pdf

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Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting

Cited by 272 publications

References 32 publications

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

Recent advances of chitosan nanoparticles as drug carriers

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

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