2003
DOI: 10.1016/j.molcatb.2003.05.004
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Preparation of enantiomerically pure (S)-flurbiprofen by an esterase from Pseudomonas sp. KCTC 10122BP

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Cited by 20 publications
(10 citation statements)
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“…2. A more complete study including such terms which break the local U(1) symmetry will be discussed elsewhere [24].…”
mentioning
confidence: 99%
“…2. A more complete study including such terms which break the local U(1) symmetry will be discussed elsewhere [24].…”
mentioning
confidence: 99%
“…Although several studies concerning the biocatalysed resolution of racemic flurbiprofen have been reported in recent years [9][10][11][12][13], there is still the need to find a strategy that could lead to a fast, automated, and easily scalable way to obtain both enantiomers of flurbiprofen. In this contest, the use of a continuous flow reactor could help to overcome some of the limitations of traditional kinetic resolutions in batch, such as long reaction times, product inhibition, and scalability.…”
Section: Introductionmentioning
confidence: 99%
“…A similar mobile phase composition (95/5/1) was used by Booth and collaborators, using the same stationary phase [15]. At a preparative scale, some examples can be found on both the enzymatic resolution of R-Flurbiprofen [16][17][18] and S-Flurbiprofen [19][20][21] enantiomers. However, as far as our knowledge, there are no published studies related to the preparative separation of flurbiprofen enantiomers by liquid chromatography.…”
Section: Introductionmentioning
confidence: 99%