“…They have been prepared as mimics of 1-aminocyclopropane carboxylic acid (ACC) with a high inhibitory activity for the ACC-deaminase and alanine racemase, 1,2 as analogues of (-)-allonorcoronamic acid, 3 as structural moieties of nucleotides, 4 as potential herbicides or plant growth regulators, 5 as potential insecticides, 6 as phosphonic analogues of the antidepressant minalcipran 7 and as constrained analogue of the GABA antagonist phaclophen. 8 Therefore, a variety of methods have been developed to prepare cyclopropylphosphonates such as the phosphonylation of halogenated cyclopropanes, 9 the decomposition of diazophosphonates, 10,11 the cyclopropanation of vinylphosphonates, [12][13][14][15] electrochemical methods, [16][17][18] the addition of phosphites to iminium salts, 19,20 fragmentation and rearrangement of epoxyethylphosphonates, 21 alkylation of benzylphosphonate carbanions with 1,2-dibromoethane 5,22 and the addition of fumarates to phosphonylated sulphonium ylides. 23 On the other hand, the Michael Induced Ring Closure (MIRC) reaction is a well established methodology for the construction of cyclopropanes using several nucleophiles 24 and for cycloalkanes in general.…”