Preparation of dye-loaded SiO2 nanoparticles

Wang, Qiang; Choy, Rebecca; Dai, Qing; Ostafin, Agnes

doi:10.1016/j.jnoncrysol.2006.12.008

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…Therefore, the leakage lowers the imaging contrast obtained with the dye-loaded NEs and can be a source of important artifacts. [42] In contrast to dye-loaded nanoparticles based on silica [144] and polymers, [145] which are generally more resistant against dye leakage due to their solid core, nanodroplets with their liquid core are more prone to the escape of dyes. As a result, they usually release their lipid content rather rapidly ranging from minutes to hours depending on the lipophilicity and the structure of the encapsulated molecule.…”

Section: Stability Of Dye-loaded Nes and Cargo Releasementioning

confidence: 99%

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Klymchenko

Liu

Collot

et al. 2020

Adv Healthcare Materials

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Lipid nanoemulsions (NEs), owing to their controllable size (20 to 500 nm), stability and biocompatibility, are now frequently used in various fields, such as food, cosmetics, pharmaceuticals, drug delivery, and even as nanoreactors for chemical synthesis. Moreover, being composed of components generally recognized as safe (GRAS), they can be considered as “green” nanoparticles that mimic closely lipoproteins and intracellular lipid droplets. Therefore, they attracted attention as carriers of drugs and fluorescent dyes for both bioimaging and studying the fate of nanoemulsions in cells and small animals. In this review, the composition of dye‐loaded NEs, methods for their preparation, and emerging biological applications are described. The design of bright fluorescent NEs with high dye loading and minimal aggregation‐caused quenching (ACQ) is focused on. Common issues including dye leakage and NEs stability are discussed, highlighting advanced techniques for their characterization, such as Förster resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS). Attempts to functionalize NEs surface are also discussed. Thereafter, biological applications for bioimaging and single‐particle tracking in cells and small animals as well as biomedical applications for photodynamic therapy are described. Finally, challenges and future perspectives of fluorescent NEs are discussed.

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Section: Stability Of Dye-loaded Nes and Cargo Releasementioning

confidence: 99%

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Klymchenko

Liu

Collot

et al. 2020

Adv Healthcare Materials

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“…Over the past decades, SiO 2 nanoparticles have been under intensive investigation through both experiments − and computer simulation − because of their enormous technological importance for advanced quantum-confined electronic and optoelectronic devices. It was found that silica nanoparticles have a number of novel properties including catalysis 24 and photoluminescence 9,17 resulting from their specific structure, which is different from the bulk.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics Simulation of Amorphous SiO₂ Nanoparticles

Hoang¹

2007

J. Phys. Chem. B

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Molecular dynamics simulation of amorphous SiO2 spherical nanoparticles has been carried out in a model with different sizes, 2, 4, and 6 nm, under non-periodic boundary conditions. We use the pair interatomic potentials which have weak Coulomb interaction and Morse type short-range interaction. Models have been obtained by cooling from the melt via molecular dynamics (MD) simulation. Structural properties of amorphous nanoparticles obtained at 350 K have been studied via partial radial distribution functions (PRDFs), mean interatomic distances, coordination numbers, and bond-angle distributions, which are compared with those observed in the bulk. Calculations of the radial density profile in nanoparticles show the tendency of oxygen to concentrate at the surface as observed previously in other amorphous clusters or thin films. Size effects on structure of nanosized models are significant. The calculations show that if the size is larger than 4 nm, amorphous SiO2 nanoparticles have a distorted tetrahedral network structure with the mean coordination number ZSi-O approximately 4.0 and ZO-Si approximately 2.0 like those observed in the bulk. Surface structure, surface energy, and glass transition temperature of SiO2 nanoparticles have been obtained and presented.

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“…Both systems are practically monodisperse, characterized by a narrow size distribution with a mean diameter of about 200 nm. Mobility measurements (data not presented here) of the silica particles (SP9AA and SPSf) in solution indicated that they are stable due to their zeta potential of about À 32 mV, which is a consequence of negative surface charge of silica particles prepared from basic catalysis [11,25,26]. If the charge density remains active and negative during preparation and growing of the silica particles, the loading of the cationic dyes used will be more likely to occur in the outer surface of the particle producing a radial distribution.…”

Section: Resultsmentioning

confidence: 86%