Preparation of dissolvable albumin stents for vascular anastomosis with a 1.9 µm laser and in vitro mechanical strength assessments

Abstract

The results show that fast-dissolving stents can be produced reliably using the extrusion technique, and sterilized by gamma-irradiation. Without stay sutures, soldered vessels exhibited low tensile strength, but burst pressures comparable to sutured vessels. It was concluded that stay sutures would be necessary in vivo due to degradation of the tensile strength of soldered vessels with exposure to moisture.

Improving the strength of sutureless laser-assisted vessel repair using preloaded longitudinal compression on tissue edge

“…Water has major peaks of the absorption coefficient at 970, 1450, 1940‐nm in near infrared wave length. 1455‐nm diode lasers were used in , and 1.9‐μm diode lasers were used in . However, 970‐nm has not been demonstrated in the literature.…”

“…Recent research has evaluated the ability of chemical materials, such as glues and/or dyes, to increase laser absorption and thus improve tissue welding strength . Most in vivo studies have used stay sutures , to approximate both edges of vessel segments and to increase tension.…”

“…Pushing the sample towards the coapted tissue end prior to irradiation may avoid tissue separation during laser irradiation. A review paper published in 2004 identified 37 relevant studies of LAVA/LAVR , and we found additional 31 relevant studies published mainly after 2004 . Of these 68 studies, 26 evaluated LAVA/LAVR without stay sutures .…”

Polymers in Cardiology

“…For example, crosslinked albumin gels were described as potential sealants for prosthetic vascular grafts [64]. In addition, albumin-based hydrogels were tested for enhancement of articular cartilage and intervertebral disc regeneration [65]. Interestingly, albumin was also investigated recently as dissolvable stent to provide intraluminal support during vascular anastomosis [66].…”