Preparation of direct compressible effervescent components: spray-dried sodium bicarbonate

Saleh, S. I.; Boymond, C.; Stamm, A.

doi:10.1016/0378-5173(88)90030-0

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Moreover, there are now directly compressible grades available, incorporating additives like PVP or silicone oil. 35…”

Section: Sodium Bicarbonatementioning

confidence: 99%

A Bird Eye View on Effervescent Drug Delivery System

Jadhav,

Gangurde

2023

IJDDT

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Effervescent drug delivery systems (EDDS) have gained significant attention in the pharmaceutical industry due to their unique characteristics and potential advantages over conventional dosage forms. This comprehensive review aims to provide an in-depth understanding of EDDS, including their formulation strategies, underlying mechanisms, and diverse applications in drug delivery. EDDS are effervescent dosage forms that release drugs upon water dissolution, leading toward carbon dioxide gas generation. The effervescence, resulting from the reaction between an acid and a base, facilitates rapid drug dissolution and enhances drug bioavailability. The primary components of an EDDS include an active pharmaceutical ingredient (API), effervescent agents (e.g., organic acids and bases), binders, disintegrants, and other excipients. Effervescent tablets, granules, powders, and effervescent-coated dosage forms are commonly employed formulations. Several factors, such as pH, temperature, solubility, and particle size, influence the drug’s effervescence process and subsequent release kinetics. The drug release mechanisms from EDDS can be attributed to various phenomena, including effervescence-driven disintegration, gas evolution, and solubilization. The effervescence-induced carbon dioxide bubbles mechanically disrupt the dosage form, leading to enhanced drug dissolution and subsequent release. Additionally, the carbon dioxide gas acts as a propellant, providing rapid drug delivery and potentially improving patient compliance. EDDS find applications in diverse therapeutic areas, including analgesics, antacids, dietary supplements, and antiviral agents. They offer several advantages, such as improved drug stability, enhanced bioavailability, increased patient convenience, and ease of administration, particularly for populations with swallowing difficulties. Furthermore, EDDS can be tailored to achieve controlled release, targeted drug delivery, and taste masking through appropriate formulation modifications. However, challenges associated with EDDS include their sensitivity to environmental conditions, potential drug degradation during effervescence, and the need for specialized packaging to maintain stability. The selection of suitable effervescent agents, excipients, and manufacturing processes is crucial to overcome these limitations and ensure consistent product performance. In conclusion, effervescent drug delivery

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“…Moreover, there are now directly compressible grades available, incorporating additives like PVP or silicone oil. 35…”

Section: Sodium Bicarbonatementioning

confidence: 99%

A Bird Eye View on Effervescent Drug Delivery System

Jadhav,

Gangurde

2023

IJDDT

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“…Because it is highly soluble and inexpensive, sodium bicarbonate is one of the most commonly utilised carbonates. 44,55,57,58 Other alkaline or alkaline earth metal carbonates that are physiologically appropriate may be employed, such as potassium carbonate or bicarbonate, calcium carbonate or bicarbonate, sodium carbonate, sodium glycine carbonate etc. 36,[59][60][61][62][63][64][65] Diluents, buffering agents, ligands, sweeteners, colouring agents, flavouring agents, solubilizers, wetting agents, disintegrants, and other commonly used excipients may be included in the formulation or preparation of effervescent tablets.…”

Section: Effect Of Water On Effervescent Formulationsmentioning

confidence: 99%

A Comprehensive Review on Effervescent Tablets

Vanhere,

Derle,

Khatale

et al. 2023

J. Drug Delivery Ther.

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Effervescent tablets are becoming increasingly popular due to their ease of administration and rapid onset of action. They typically contain acidic materials and carbonates or bicarbonates that react quickly in the presence of water, releasing carbon dioxide and improving API solubility and flavour masking. However, effervescent tablets can be bulky, and the reaction rate is difficult to control due to water's catalytic effect. This article discusses the advantages and disadvantages of effervescent tablets, common effervescent reactions, active ingredients that can be formulated, and the preparation and manufacturing process. It also evaluates effervescent granules and tablets and explores the latest advancements in effervescent technology. Overall, effervescent tablets offer a promising option for drug delivery, and ongoing research will undoubtedly yield even more advanced formulations in the future. Keywords: Effervescent granules, Effervescent tablets, Hot melt granulation, Carbon dioxide content, Water activity

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“…Co-spray dried mannitol with 20% PVP gave the highest tensile strength at all applied pressures. Saleh et al [121] spray dried sodium bicarbonate using PVP and silicone oil as auxiliary additives. These additives significantly improved the compressibility of sodium bicarbonate.…”

Section: Inorganic-basedmentioning

confidence: 99%

Spray Drying for Direct Compression of Pharmaceuticals

et al. 2021

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Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.

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Preparation of direct compressible effervescent components: spray-dried sodium bicarbonate

Cited by 6 publications

References 5 publications

A Bird Eye View on Effervescent Drug Delivery System

A Bird Eye View on Effervescent Drug Delivery System

A Comprehensive Review on Effervescent Tablets

Spray Drying for Direct Compression of Pharmaceuticals

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