Preparation of deer oil powder and its effect on acute gastric mucosal injury in rats

Xia, Yunlong; Li, Zhi-Man; Liu, Chang; Mu, Rui; Bo, Pan-Pan; Wang, Zi; Sun, Yinshi

doi:10.1111/jfbc.14088

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric ulcer, one of the most constant digestive disorders with an increasing incidence and prevalence, is afecting millions of people yearly [1,2]. Various stimulus including alcohol and nonsteroidal anti-infammatory medications can cause increasing incidences of gastric ulcer [3]; the imbalance between these stimulating factors and gastric mucosal protective factors (mucin and prostaglandins) leads to gastric mucosal lesions.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors’ Identification of NF-κB Signaling

Guo

Gong

et al. 2023

Journal of Food Biochemistry

View full text Add to dashboard Cite

Paederia scandens (Lour.) Merr. (P. scandens), as an edible and medicinal herb, is commonly used for treating gastric ulcer in China; however, its mechanistic and effective substances’ studies remain limited. This study aimed to investigate the antigastric ulcer effects of aqueous extracts of P. scandens (PS-AE) and explore the involvement of NF-κB signaling in this effect. In addition, the study aimed to identify the effective substances by exploring NF-κB inhibitors. The main components of PS-AE were identified using an UPLC-MS method. HCl/EtOH-induced acute gastric ulcer in rats, and LPS-stimulated RAW264.7 cells were used to determine the antigastric ulcer effects of PS-AE in vivo and in vitro, respectively. Histopathological changes of the ulcer tissues were observed using staining methods of HE and PAS; secretions of inflammatory cytokines and oxidative stress indexes were measured using biochemical test kits; protein levels of NF-κB signaling pathway-related molecules were measured using Western Blot. NF-κB inhibitors’ identification in P. scandens was performed by developing HipHop pharmacophore model, and the results were further validated by molecular docking. In vivo, PS-AE significantly attenuated gastric ulcer in rats; reduced inflammation by adjusting the inflammatory cytokines TNF-α, IL-1β, and IL-6 levels; and induced oxidative stress can be alleviated via adjusting the levels of SOD, MDA, and GSH-Px. In addition, PS-AE may play an anti-inflammatory role mainly through NF-κB signaling pathway. Following pharmacophore modeling and molecular docking, 13 potential inhibitors targeting NF-κB were identified. In addition, in vitro, PS-AE and paederoside could significantly inhibit the activation of NF-κB p65 and the productions of downstream cytokines including NO, TNF-α, and IL-6. PS-AE protective effects on gastric ulcer damage induced by HCl/EtOH in rats, which is probably associated with its antioxidant effect and the inhibitory effects on levels of inflammatory mediators regulated by NF-κB signaling pathway. 13 potential NF-κB-targeting inhibitors are probably effective substances contributing to the herb’s pharmacological effect. In practical application, Paederia scandens, a traditional food and medicinal plant, possessed diversified chemical components and multiple pharmacological activities (anti-inflammatory, bacteriostasis, and antioxidative.). In China, P. scandens has been used as a traditional medicine to treat gastritis for hundreds of years, and it may be a potentially effective dietary product to improve gastric ulcer. This study shows that P. scandens exerts protective effects on gastric ulcer damage induced by HCl/EtOH in rats, which is probably associated with its antioxidant effect and the inhibitory effects on levels of inflammatory mediators regulated by NF-κB signaling pathway, which provides pharmacological justifications for the functional food use of P. scandens for treating gastric disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors’ Identification of NF-κB Signaling

Guo

Gong

et al. 2023

Journal of Food Biochemistry

View full text Add to dashboard Cite

show abstract

Bovine lactoferrin inhibits resistant Helicobacter pylori in vitro and protects gastric mucosal injury in vivo

Wang¹,

Cai²,

Liu³

et al. 2023

International Dairy Journal

View full text Add to dashboard Cite

Histological study on the effect of açai berry extract in the treatment of fundic mucosal injury in adult male albino rat

Khallaf,

Saeid,

Laag

et al. 2024

TAMJ

View full text Add to dashboard Cite

Background Gastric injury is a worldwide medical problem. It is caused by many factors. Açai berry is a fruit with many potential medical properties that gained much international interest. Aim To evaluate the possible role of açai berry extract in the treatment of fundic mucosal injury in adult male albino rats. Materials and methods This work was done on 40 adult male albino rats that were divided into; group I (control) (10 rats), group II (10 rats) which were given açai berry extract orally at a dose of 300 mg/kg once per day for 14 days, group III (10 rats) which were given a single dose of diclofenac orally at a dose of 100 mg/kg for induction of gastric injury, and group IV (10 rats) that were given single oral dose of diclofenac then received açai berry extract for 14 days. Specimens from the fundus were processed and stained by hematoxylin and eosin. Results Group III showed exfoliation of surface epithelial cells and gastric glands, infiltration of lamina propria with inflammatory cells, and congestion of the blood vessels. Cytoplasmic vacuolations were detected in different cells. Group IV revealed improved changes that were detected in group III. Conclusion Açai berry extract is effective in the treatment of gastric injury.

show abstract

Preparation of deer oil powder and its effect on acute gastric mucosal injury in rats

Cited by 3 publications

References 15 publications

Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors’ Identification of NF-κB Signaling

Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors’ Identification of NF-κB Signaling

Bovine lactoferrin inhibits resistant Helicobacter pylori in vitro and protects gastric mucosal injury in vivo

Histological study on the effect of açai berry extract in the treatment of fundic mucosal injury in adult male albino rat

Contact Info

Product

Resources

About