Preparation of Curdlan sulphate - Chitosan nanoparticles as a drug carrier to target Mycobacterium smegmatis infected macrophages

Ravindran, Radhika; Mitra, Kartik; Arumugam, Senthil Kumar; Doble, Mukesh

doi:10.1016/j.carbpol.2021.117686

Cited by 17 publications

(3 citation statements)

References 55 publications

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“…Sulphonic CS is good flocculants for metallic oxides [13]. Ravindran et al [34] prepared curdlan sulfate-chitosan nanoparticles were through the PEC method at a mass ratio of 2:1 respectively. A first-line tuberculosis drug, Rifampicin (Rif) and a phytochemical, DdPinitol (d-PIN), were encapsulated into Curdlan Sulphate (CuS)-chitosan nanoparticles (CuS/CS NPs) of size 205.41 ± 7.24 nm.…”

Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

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“…Natural polysaccharides have been proposed as materials from which to produce functional materials and alternatives to petroleum-based materials. The use of polysaccha- rides has been proposed for drug carriers with slow release function [ 1 , 2 , 3 ], complex films with antibacterial properties [ 4 , 5 ], etc. Xylan, the second most widespread polysaccharide after cellulose, can be enhanced or given new capabilities by the introduction of new groups.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of a Novel Glycidyl Metharcylate/Phaytic Acid-Based on Bagasse Xylan Composite Derivative

Liu

et al. 2021

Polymers

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The development of natural biomass materials with excellent properties is an attractive way to improve the application range of natural polysaccharides. Bagasse Xylan (BX) is a natural polysaccharide with various biological activities, such as antitumor, antioxidant, etc. Its physic-chemical and biological properties can be improved by functionalization. For this purpose, a novel glycidyl metharcylate/phytic acid based on a BX composite derivative was synthesized by a free radical polymerization technique with glycidyl metharcylate (GMA; GMABX) and further esterification with phytic acid (PA; GMABX-PA) in ionic liquid. The effects of the reaction conditions (i.e., temperature, time, initiator concentration, catalyst concentration, GMA concentration, PA concentration, mass of ionic liquid) on grafting rate(G), conversion rate(C) and degree of substitution(DS) are discussed. The structure of the composite material structure was confirmed by FTIR, 1H NMR and XRD. SEM confirmed the particle morphology of the composite derivative. The thermal stability of GMABX-PA was determined by TG-DTG. Molecular docking was further performed to study the combination mode of the GMABX-PA into the active site of two lung cancer proteins (5XNV, 2EB2) and a blood cancer protein (2M6N). In addition, tumor cell proliferation inhibition assays for BX, GMABX-PA were carried out using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetraz -olium bromide (MTT) method. The results showed that various reaction conditions exhibited favorable gradient curves, and that a maximum G of 56% for the graft copolymerization and a maximum DS of 0.267 can be achieved. The thermal stability was significantly improved, as demonstrated by the fact that there was still 60% residual at 800 °C. The molecular docking software generated satisfactory results with regard to the evaluated binding energy and combining sites. The inhibition ratio of GMABX-PA on NCI-H460 (lung cancer cells) reached 29.68% ± 4.45%, which is five times higher than that of BX. Therefore, the material was shown to be a potential candidate for biomedical applications as well as for use as a heat resistant material.

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“…Commercially available curdlan β‐1,3‐glucan, 1 has been used as a gelling and thickening agent in food additives, 2 packing films, 3,4 and drug carriers, 5,6 because of its low toxicity, ability to gel upon heating, and modifiable properties. Compared to cellulose, curdlan is easily soluble in alkaline aqueous solutions and organic solvents such as formic acid and dimethyl sulfoxide.…”

Section: Introductionmentioning

confidence: 99%

Chemically induced strengthening of curdlan alkylcarbamate thermoplastics

Ozawa

Kawashima

Kijima

2021

J of Applied Polymer Sci

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Curdlan alkylcarbamate (CrdC) with a degree of substitution (DS) of ~2 was chemically modified via postesterification using carboxylic anhydride at a residual OH. Fully substituted mixed esters of curdlan carbamate/carboxylate (CrdCE) (DS = 3) with carbamate hydrogen bonding ability were obtained in high yields (>80%). Owing to replacing the residual OH with alkanoates, the glass transition temperature of CrdCE was lower than that of the corresponding CrdC. All the CrdCE displayed a greater deformability evaluated by elongation at break, being more remarkable when introducing longer esters (almost two times higher than the unmodified CrdC) than shorter esters (1.4 times higher). On the other hand, the effect on both Young's modulus and tensile strength depended on the length of the esters, observing an increase on both parameters when using shorter esters (19% and 17% higher, respectively), and a decrease for longer esters (33% and 6% lower, respectively). Thus, it was established that the physical properties of the thermoplastic CrdC could be controlled by modifying the residual OH with an appropriate ester group.

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Preparation of Curdlan sulphate - Chitosan nanoparticles as a drug carrier to target Mycobacterium smegmatis infected macrophages

Cited by 17 publications

References 55 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Synthesis and Biological Evaluation of a Novel Glycidyl Metharcylate/Phaytic Acid-Based on Bagasse Xylan Composite Derivative

Chemically induced strengthening of curdlan alkylcarbamate thermoplastics

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