Preparation of Crystallinity Tailored Silk Fibroin-Sodium Alginate Based Floating Microbeads for Nevirapine Delivery
BHUPESH DIGAMBAR PATIL,
SOPAN NAMDEV NANGARE,
LAXMIKANT RAMVALLABH ZAWAR
Abstract:The present work anticipated crystallinity-tuned silk fibroin (SFIB)-sodium alginate floating microbeads (MB) as a candidate for nevirapine (NEV) sustained release. Briefly, crystallinity tuning was accomplished using solvent annealing. The changes in structural conformation of SFIB were validated using FTIR spectroscopy. Here, the tangent baseline method revealed changes in crystallinity of floating NEV-loaded SFIB-MB. Importantly, solvent annealing offers conversion of amorphous ‘α-helix’ to crystalline ‘β-s… Show more
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